Cristin-resultat-ID: 1482481
Sist endret: 19. februar 2018, 15:08
NVI-rapporteringsår: 2017
Resultat
Vitenskapelig artikkel
2017

Trajectories of depressive symptoms and their relationship to the progression of dementia

Bidragsytere:
  • Maria Lage Barca
  • Karin Persson
  • Rannveig Sakshaug Eldholm
  • Jurate Saltyte Benth
  • Hege Kersten
  • Anne Brita Knapskog
  • mfl.

Tidsskrift

Journal of Affective Disorders
ISSN 0165-0327
e-ISSN 1573-2517
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2017
Publisert online: 2017
Volum: 222
Sider: 146 - 152
Open Access

Importkilder

Scopus-ID: 2-s2.0-85022065661

Beskrivelse Beskrivelse

Tittel

Trajectories of depressive symptoms and their relationship to the progression of dementia

Sammendrag

Background The relationship between progression of Alzheimer's disease and depression and its underlying mechanisms has scarcely been studied. Methods A sample of 282 outpatients with Alzheimer's disease (AD; 105 with amnestic AD and 177 with Alzheimer's dementia) from Norway were followed up for an average of two years. Assessment included Cornell Scale for Depression in Dementia and Clinical Dementia Rating Scale (CDR) at baseline and follow-up to examine the relationship between AD and depression. Additionally, MRI of the brain, CSF dementia biomarkers and APOE status were assessed at baseline. Progression of dementia was defined as the difference between CDR sum of boxes at follow-up and baseline (CDR-SB change). Trajectories of depressive symptoms on the Cornell Scale were identified using growth mixture modeling. Differences between the trajectories in regard to patients’ characteristics were investigated. Results Three distinct trajectories of depressive symptoms were identified: 231 (82.8%) of the patients had stable low-average scores on the Cornell Scale (Class 1); 11 (3.9%) had high and decreasing scores (Class 2); and 37 (13.3%) had moderate and increasing scores (Class 3). All classes had average probabilities over 80%, and confidence intervals were non-overlapping. The only significant characteristic associated with membership in class 3 was CDR-SB change. Limitations Not all patients screened for participation were included in the study, but the included and non-included patients did not differ significantly. Some patients with amnestic MCI might have been misdiagnosed. Conclusion A more rapid progression of dementia was found in a group of patients with increasing depressive symptoms.

Bidragsytere

Maria Lage Barca

  • Tilknyttet:
    Forfatter
    ved Geriatrisk avdeling ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Nasjonalt senter for aldring og helse ved Sykehuset i Vestfold HF

Karin Ester Torun Persson

Bidragsyterens navn vises på dette resultatet som Karin Persson
  • Tilknyttet:
    Forfatter
    ved Geriatrisk avdeling ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Nasjonalt senter for aldring og helse ved Sykehuset i Vestfold HF

Rannveig Sakshaug Eldholm

  • Tilknyttet:
    Forfatter
    ved Institutt for nevromedisin og bevegelsesvitenskap ved Norges teknisk-naturvitenskapelige universitet
Aktiv cristin-person

Jurate Saltyte Benth

  • Tilknyttet:
    Forfatter
    ved Helsetjenesteforskning (HØKH) ved Akershus universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Klinikk for helsetjenesteforskning og psykiatri ved Universitetet i Oslo

Hege Kersten

  • Tilknyttet:
    Forfatter
    ved Seksjon for farmakologi og farmasøytisk ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Fag- og forskning ved Sykehuset Telemark HF
  • Tilknyttet:
    Forfatter
    ved Nasjonalt senter for aldring og helse ved Sykehuset i Vestfold HF
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