Cristin-resultat-ID: 1489686
Sist endret: 31. oktober 2017 14:15
NVI-rapporteringsår: 2017
Resultat
Vitenskapelig artikkel
2017

Comorbid post-traumatic stress disorder in alcohol use disorder: relationships to demography, drinking and neuroimmune profile

Bidragsytere:
  • Sudan Prasad Neupane
  • Jørgen Gustav Bramness og
  • Lars Lien

Tidsskrift

BMC Psychiatry
ISSN 1471-244X
e-ISSN 1471-244X
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2017
Publisert online: 2017
Volum: 17
Hefte: 312
Sider: 1 - 10
Open Access

Importkilder

Scopus-ID: 2-s2.0-85028455164

Beskrivelse Beskrivelse

Tittel

Comorbid post-traumatic stress disorder in alcohol use disorder: relationships to demography, drinking and neuroimmune profile

Sammendrag

BACKGROUND: This study examined how alcohol use disorder (AUD) patients with post-traumatic stress disorder (PTSD) differed from those without PTSD in terms of demography, drinking patterns and C-reactive protein, inflammatory cytokines, tryptophan metabolism parameters, and brain-derived neurotrophic factor (BDNF). METHODS: A consecutive sample (N = 187) of treatment-receiving AUD individuals were recruited from Nepalese facilities. They underwent fully structured psychiatric interviews. Serum levels of inflammatory cytokines [interleukin (IL)-6, IL-1 Receptor antagonist (IL-1Ra), IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ)] were determined by a multiplex assay, kynurenine and tryptophan levels by high-performance liquid chromatography, and BDNF by enzyme-linked immunosorbent assay (ELISA). RESULTS: The prevalence of exposure to severe trauma and PTSD was 74% and 17%, respectively. PTSD comorbidity was not associated with age, gender, or socioeconomic status, but with co-occurring major depression, history of attempted suicide, earlier peak of drinking problems, higher drinking quantity and withdrawal symptoms, experiencing alcoholic blackouts, and drinking problems among parents. None of the assessed neuroimmune parameters was related to comorbid PTSD. CONCLUSIONS: The findings support routine trauma screening in AUD treatment samples and screening for risky drinking in trauma populations to help guide interventions. The expected aberrations in neuroimmune functioning may not be found when examined in a sample with multiple psychiatric morbidities

Bidragsytere

Aktiv cristin-person

Sudan Neupane

Bidragsyterens navn vises på dette resultatet som Sudan Prasad Neupane
  • Tilknyttet:
    Forfatter
    ved Senter for rus- og avhengighetsforskning ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF

Jørgen Gustav Bramness

  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF
Aktiv cristin-person

Lars Lien

  • Tilknyttet:
    Forfatter
    ved Institutt for helse- og sykepleievitenskap ved Høgskolen i Innlandet
  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF
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