Cristin-resultat-ID: 1495247
Sist endret: 9. mars 2018 12:58
NVI-rapporteringsår: 2017
Resultat
Vitenskapelig artikkel
2017

Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

Bidragsytere:
  • Karri Silventoinen
  • Aline Jelenkovic
  • Reijo Sund
  • Yoshie Yokoyama
  • Yoon-Mi Hur
  • Wendy Cozen
  • mfl.

Tidsskrift

American Journal of Clinical Nutrition
ISSN 0002-9165
e-ISSN 1938-3207
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2017
Volum: 106
Hefte: 2
Sider: 457 - 466

Importkilder

Scopus-ID: 2-s2.0-85026665173

Beskrivelse Beskrivelse

Tittel

Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

Sammendrag

Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m(2))], but factors modifying these variance components are poorly understood. Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. Design: We used genetic structural equation modeling to analyze BMI in twins >= 20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 2029 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI. Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.

Bidragsytere

Karri Silventoinen

  • Tilknyttet:
    Forfatter
    ved Osaka Daigaku
  • Tilknyttet:
    Forfatter
    ved Helsingin yliopisto / Helsingfors universitet

Aline Jelenkovic

  • Tilknyttet:
    Forfatter
    ved Helsingin yliopisto / Helsingfors universitet
  • Tilknyttet:
    Forfatter
    ved Universidad del País Vasco

Reijo Sund

  • Tilknyttet:
    Forfatter
    ved Helsingin yliopisto / Helsingfors universitet
  • Tilknyttet:
    Forfatter
    ved Itä-Suomen Yliopisto

Yoshie Yokoyama

  • Tilknyttet:
    Forfatter
    ved Osaka Shiritsu Daigaku

Yoon-Mi Hur

  • Tilknyttet:
    Forfatter
    ved Mokpo National University
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