Cristin-resultat-ID: 1513784
Sist endret: 11. juli 2018, 13:31
NVI-rapporteringsår: 2017
Resultat
Vitenskapelig artikkel
2018

Cellular responses of human astrocytoma cells to dust from the Acheson process. An in vitro study

Bidragsytere:
  • Yke Jildouw Arnoldussen
  • Torunn Kringlen Ervik
  • Balazs Berlinger
  • Ida Kero
  • Sergey Shaposhnikov og
  • Shanbeh Zienolddiny

Tidsskrift

Neurotoxicology
ISSN 0161-813X
e-ISSN 1872-9711
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Publisert online: 2017
Volum: 65
Sider: 241 - 247
Open Access

Importkilder

Scopus-ID: 2-s2.0-85032927588

Beskrivelse Beskrivelse

Tittel

Cellular responses of human astrocytoma cells to dust from the Acheson process. An in vitro study

Sammendrag

Silicon carbide (SiC) is largely used in various products such as diesel particulate filters and solar panels. It is produced through the Acheson process where aerosolized fractions of SiC and other by-products are generated in the work environment and may potentially affect the workers’ health. In this study, dust was collected directly on a filter in a furnace hall over a time period of 24 h. The collected dust was characterized by scanning electron microscopy and found to contain a high content of graphite particles, and carbon and silicon containing particles. Only 6% was classified as SiC, whereof only 10% had a fibrous structure. To study effects of exposure beyond the respiratory system, neurotoxic effects on human astrocytic cells, were investigated. Both low, occupationally relevant, and high doses from 9E-6 mg/cm2 up to 4.5 mg/cm2were used, respectively. Cytotoxicity assay indicated no effects of low doses but an effect of the higher doses after 24 h. Furthermore, investigation of intracellular reactive oxygen species (ROS) indicated no effects with low doses, whereas a higher dose of 0.9 mg/cm2 induced a significant increase in ROS and DNA damage. In summary, low doses of dust from the Acheson process may exert no or little toxic effects, at least experimentally in the laboratory on human astrocytes. However, higher doses have implications and are likely a result of the complex composition of the dust. © 2017 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND

Bidragsytere

Yke Jildouw Arnoldussen

  • Tilknyttet:
    Forfatter
    ved Statens arbeidsmiljøinstitutt

Torunn Kringlen Ervik

  • Tilknyttet:
    Forfatter
    ved Statens arbeidsmiljøinstitutt

Balazs Berlinger

  • Tilknyttet:
    Forfatter
    ved Statens arbeidsmiljøinstitutt

Ida Teresia Kero

Bidragsyterens navn vises på dette resultatet som Ida Kero
  • Tilknyttet:
    Forfatter
    ved Metallproduksjon og prosessering ved SINTEF AS

Sergey Shaposhnikov

  • Tilknyttet:
    Forfatter
    ved Comet BioTech AS
  • Tilknyttet:
    Forfatter
    ved Diverse norske bedrifter og organisasjoner
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