Cristin-resultat-ID: 1584232
Sist endret: 31. desember 2018 13:33
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment

Bidragsytere:
  • Helge Prytz Toft
  • Sudan Prasad Neupane
  • Jørgen Gustav Bramness
  • Terje Tilden
  • Bruce E. Wampold og
  • Lars Lien

Tidsskrift

BMC Psychiatry
ISSN 1471-244X
e-ISSN 1471-244X
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Publisert online: 2018
Trykket: 2018
Volum: 18
Hefte: 95
Open Access

Importkilder

Scopus-ID: 2-s2.0-85045210568

Beskrivelse Beskrivelse

Tittel

The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment

Sammendrag

Background Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol into account. Methods The study was a cross-sectional assessment of patients at admission to a specialized psychiatric center in Norway. A total of 128 patients were included. Information was gathered using the self-administered questionnaires Beck Depression Inventory-II (BDI-II) and the Alcohol Use Disorders Identification Test (AUDIT), in addition to clinical interviews recording childhood or adult life trauma. Serum levels of the cytokines Interleukin-1β (IL-1β), Interleukin-1 Receptor Antagonist (IL-1RA), Tumor Necrosis Factor-α (TNF-α) and the chemokine Monocyte Chemoattractant Protein-1 (MCP-1) were assessed. A Luminex bead-based multiplex assay was used for cytokine measurements. Patient cytokine levels were compared to those of healthy volunteers by the Mann-Whitney U test. Results Levels of cytokines did not differ across patients with mild, moderate and severe depression. AUDIT score was not related to cytokine levels, but to level of depression. A history of trauma was related to higher levels of IL-1RA and TNF-α (p = 0.048 and p = 0.033, respectively), especially among the severely depressed. Serum levels of MCP-1 and TNF-α were significantly higher among psychiatric patients than in healthy volunteers. Conclusions Findings indicate that depression was not related to levels of circulating cytokines among patients in treatment, but that traumatized patients had higher levels of IL-1RA and TNF-α than patients without trauma experience. The lack of relationship between cytokine level and depression was evident both in those without and with trauma.

Bidragsytere

Helge Prytz Toft

  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Senter for rus- og avhengighetsforskning ved Universitetet i Oslo
Aktiv cristin-person

Sudan Neupane

Bidragsyterens navn vises på dette resultatet som Sudan Prasad Neupane
  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Senter for rus- og avhengighetsforskning ved Universitetet i Oslo

Jørgen Gustav Bramness

  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Psykiatri ved UiT Norges arktiske universitet

Terje Tilden

  • Tilknyttet:
    Forfatter
    ved Modum Bad

Bruce E. Wampold

  • Tilknyttet:
    Forfatter
    ved University of Wisconsin-Madison
  • Tilknyttet:
    Forfatter
    ved Modum Bad
1 - 5 av 6 | Neste | Siste »