Cristin-resultat-ID: 1591193
Sist endret: 13. september 2018 09:48
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

Agreement between paternal self-reported medication use and records from a national prescription database

Bidragsytere:
  • Jacqueline M. Cohen
  • Mollie Wood
  • Sonia Hernandez-Diaz og
  • Hedvig Marie Egeland Nordeng

Tidsskrift

Pharmacoepidemiology and Drug Safety
ISSN 1053-8569
e-ISSN 1099-1557
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Volum: 27
Hefte: 4
Sider: 413 - 421
Open Access

Importkilder

Scopus-ID: 2-s2.0-85042536471

Beskrivelse Beskrivelse

Tittel

Agreement between paternal self-reported medication use and records from a national prescription database

Sammendrag

PurposeFather's medication use is of interest in fertility studies and as negative control exposures in pregnancy medication safety studies. We sought to compare self-report to prescription records to understand how reliably each of these sources of information may be used. MethodsWe compared self-reported medication use in the 6 months prior to pregnancy from fathers participating in the Norwegian Mother and Child Cohort Study to records of dispensed prescriptions from the Norwegian Prescription Database that overlapped in time. Medications from 3 main categories were assessed: prescription medications used chronically, prescription medications used episodically, and over-the-counter/prescription medications (predominantly obtained without prescription). We calculated agreement between self-report and dispensing records using Cohen's kappa statistic. ResultsWe included 42848 pregnancies with the father's prescription data available for the 9 months before pregnancy. Prescription medications used chronically including antiepileptics, antipsychotics, and antidepressants showed substantial agreement between self-report and prescription records: kappa statistics 0.87, 0.63, and 0.74, respectively. Prescription medications used episodically like anti-infectives, opioids, anxiolytics, and hypnotics and sedatives showed worse agreement: kappa 0.19, 0.32, 0.40, 0.32. Over-the-counter/prescription medications like paracetamol and nonsteroidal anti-inflammatory drugs had slight agreement: kappa 0.02 and 0.20. ConclusionsThere is good agreement between paternal self-report and prescription data for prescribed medications used chronically and substantially less for medications used episodically. Suboptimal agreement for episodic medications suggests poor recall (for questionnaires) or false positives due to noncompliance (prescription data). Not surprisingly, use of medications available both with and without a prescription is not well captured using prescription databases alone.

Bidragsytere

Jacqueline M. Cohen

  • Tilknyttet:
    Forfatter
    ved Harvard School of Public Health

Mollie Wood

  • Tilknyttet:
    Forfatter
    ved Galenisk farmasi og samfunnsfarmasi ved Universitetet i Oslo

Sonia Hernandez-Diaz

  • Tilknyttet:
    Forfatter
    ved Harvard School of Public Health
Aktiv cristin-person

Hedvig Marie Egeland Nordeng

  • Tilknyttet:
    Forfatter
    ved Avdeling for barns helse og utvikling ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved Galenisk farmasi og samfunnsfarmasi ved Universitetet i Oslo
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