Cristin-resultat-ID: 1611058
Sist endret: 3. februar 2019 11:08
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress.

Bidragsytere:
  • Helge Prytz Toft
  • Jørgen Gustav Bramness
  • Lars Lien
  • Dawit Shawel Abebe
  • Bruce E. Wampold
  • Terje Tilden
  • mfl.

Tidsskrift

Neuropsychiatric Disease and Treatment
ISSN 1176-6328
e-ISSN 1178-2021
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Publisert online: 2018
Volum: 14
Sider: 2367 - 2378
Open Access

Importkilder

Scopus-ID: 2-s2.0-85057529932

Beskrivelse Beskrivelse

Tittel

PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress.

Sammendrag

Background: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment. Methods: The study was a longitudinal assessment of 124 patients (88 women and 36 men) in treatment at Modum Psychiatric Center, Norway. The patient sample comprised a mixed psychiatric population of whom 39 were diagnosed with posttraumatic stress disorder (PTSD). Serum blood samples for cytokine analysis and measures of mental distress using Global Severity Index were collected at admission (T0), halfway (T1), and before discharge (T2). Other factors assessed were age, gender, and the use of antidepressants and anti-inflammatory drugs. Multilevel modeling was used for longitudinal analyses to assess the repeated cytokine samples within each patient. Results: Overall level of IL-1RA was higher in PTSD patients when compared to those without PTSD (P=0.021). The level of IL-1β, MCP-1, and TNF-α increased over time in PTSD compared to non-PTSD patients (P=0.025, P=0.011 and P=0.008, respectively). All patients experienced reduced mental distress as measured by self-reported Global Severity Index scores. Stratified analysis showed that PTSD patients who used anti-inflammatory drugs had higher levels of IL-1β (P=0.007) and TNF-α (P=0.049) than PTSD patients who did not use such drugs. Conclusion: The study indicates that traumatized patients may have a distinct neuroimmune development during recovery. Their activated immune system shows even further activation during their rehabilitation despite symptom reduction.

Bidragsytere

Helge Prytz Toft

  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Senter for rus- og avhengighetsforskning ved Universitetet i Oslo

Jørgen Gustav Bramness

  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Psykiatri ved UiT Norges arktiske universitet
Aktiv cristin-person

Lars Lien

  • Tilknyttet:
    Forfatter
    ved Institutt for helse- og sykepleievitenskap ved Høgskolen i Innlandet
  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF

Dawit Shawel Abebe

  • Tilknyttet:
    Forfatter
    ved Avd Rusrelatert psykiatri og avhengighet ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Institutt for sykepleie og helsefremmende arbeid ved OsloMet - storbyuniversitetet

Bruce E. Wampold

  • Tilknyttet:
    Forfatter
    ved Modum Bad
  • Tilknyttet:
    Forfatter
    ved University of Wisconsin-Madison
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