Sammendrag
Introduction: The chemical defensome comprises an integrated network of gene families and pathways that together function to metabolize and eliminate harmful compounds. It is critical for survival and highly conserved from invertebrates to fish and mammals. But the chemical defense genes of Atlantic cod (Gadus morhua), a commercially and ecologically important species, are poorly studied. The object of this study is to look into the chemical defensome network of cod and compare it with those in zebrafish (Danio rerio) and human (Homo sapiens).
Methods: Based on available literature on genes involved in the chemical defensome, we searched the zebrafish and human genomes, as well as the newly curated Atlantic cod genome assembly, to identify the genes comprising the defensome networks. Furthermore, by using the protein- protein interactions covered by the STRING database, we modeled the complex networks of genes and interactions involved in the chemical defense responses and visualized them in Cystoscape.
Results and discussion: The modelling of fish and human chemical defensome enables a dynamic visualization of these complex networks. The species-specific networks also indicate a different regulation/interaction between the different phases of chemical compound metabolisation. In zebrafish, the interactions dominate between oxygenases of Phase I and the transporters of Phase 0 and III; however, in cod and human, the interactions dominate between oxygenases and transferases of Phase II.
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