Cristin-resultat-ID: 1612354
Sist endret: 22. september 2018, 11:44
Resultat
Vitenskapelig foredrag
2018

Modelling the chemical defensome networks --- a dynamic visualisation of the involved genes and interactions in two fish species and human

Bidragsytere:
  • Xiaokang Zhang
  • Marta Eide
  • Odd Andre Karlsen
  • Eileen Marie Hanna
  • Nello Blaser
  • Pål Puntervoll
  • mfl.

Presentasjon

Navn på arrangementet: The 2nd annual conference of Digital Life Norway Research School
Sted: Stiklestad
Dato fra: 30. mai 2018
Dato til: 1. juni 2018

Arrangør:

Arrangørnavn: Centre for Digital Life Norway

Om resultatet

Vitenskapelig foredrag
Publiseringsår: 2018

Klassifisering

Vitenskapsdisipliner

Matematikk og naturvitenskap

Beskrivelse Beskrivelse

Tittel

Modelling the chemical defensome networks --- a dynamic visualisation of the involved genes and interactions in two fish species and human

Sammendrag

Introduction: The chemical defensome comprises an integrated network of gene families and pathways that together function to metabolize and eliminate harmful compounds. It is critical for survival and highly conserved from invertebrates to fish and mammals. But the chemical defense genes of Atlantic cod (Gadus morhua), a commercially and ecologically important species, are poorly studied. The object of this study is to look into the chemical defensome network of cod and compare it with those in zebrafish (Danio rerio) and human (Homo sapiens). Methods: Based on available literature on genes involved in the chemical defensome, we searched the zebrafish and human genomes, as well as the newly curated Atlantic cod genome assembly, to identify the genes comprising the defensome networks. Furthermore, by using the protein- protein interactions covered by the STRING database, we modeled the complex networks of genes and interactions involved in the chemical defense responses and visualized them in Cystoscape. Results and discussion: The modelling of fish and human chemical defensome enables a dynamic visualization of these complex networks. The species-specific networks also indicate a different regulation/interaction between the different phases of chemical compound metabolisation. In zebrafish, the interactions dominate between oxygenases of Phase I and the transporters of Phase 0 and III; however, in cod and human, the interactions dominate between oxygenases and transferases of Phase II.

Bidragsytere

Xiaokang Zhang

  • Tilknyttet:
    Forfatter
    ved Institutt for informatikk ved Universitetet i Bergen
Aktiv cristin-person

Marta Eide

  • Tilknyttet:
    Forfatter
    ved Institutt for biovitenskap (BIO) ved Universitetet i Bergen

Odd André Karlsen

Bidragsyterens navn vises på dette resultatet som Odd Andre Karlsen
  • Tilknyttet:
    Forfatter
    ved Institutt for biovitenskap (BIO) ved Universitetet i Bergen

Eileen Marie Hanna

  • Tilknyttet:
    Forfatter
    ved Institutt for informatikk ved Universitetet i Bergen

Nello Blaser

  • Tilknyttet:
    Forfatter
    ved Matematisk institutt ved Universitetet i Bergen
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