Cristin-resultat-ID: 1621821
Sist endret: 19. februar 2019, 15:39
Resultat
Short communication
2018

Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation

Bidragsytere:
  • Hallvard Lauritz Olsvik
  • Steingrim Svenning
  • Yakubu Princely Abudu
  • Andreas Brech
  • Harald Stenmark
  • Terje Johansen
  • mfl.

Tidsskrift

Autophagy
ISSN 1554-8627
e-ISSN 1554-8635
NVI-nivå 2

Om resultatet

Short communication
Publiseringsår: 2018
Publisert online: 2018
Trykket: 2018
Volum: 15
Hefte: 1
Sider: 182 - 183

Importkilder

Scopus-ID: 2-s2.0-85055568643

Beskrivelse Beskrivelse

Tittel

Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation

Sammendrag

Starvation is a fundamental type of stress naturally occurring in biological systems. All organisms have therefore evolved different safeguard mechanisms to cope with deficiencies in various types of nutrients. Cells, from yeast to humans, typically respond to amino acid starvation by initiating degradation of cellular components by inducing autophagy. This degradation releases metabolic building blocks to sustain essential core cellular processes. Increasing evidence indicates that starvation-induced autophagy also acts to prepare cells for prolonged starvation by degrading key regulators of different cellular processes. In a recent study, we found that within the first hours of amino acid starvation cells elicit an autophagic response causing rapid degradation of specific proteins. The response is executed independently of both MTOR and canonical macroautophagy. Based on RNAi-mediated knockdown of essential components of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery and electron microscopy we conclude that the response relies on some sort of endosomal microautophagy, hence vesicle budding into endosomes. Substantiated by the different substrates that are selectively degraded by this novel pathway we propose that the response predominantly acts to prepare cells for prolonged starvation. Intriguingly, this includes shutting down selective macroautophagy in preparation for a massive induction of bulk macroautophagy.

Bidragsytere

Hallvard Lauritz Olsvik

  • Tilknyttet:
    Forfatter
    ved Autophagy Research Group ved UiT Norges arktiske universitet

Steingrim Svenning

  • Tilknyttet:
    Forfatter
    ved Autophagy Research Group ved UiT Norges arktiske universitet

Yakubu Princely Abudu

  • Tilknyttet:
    Forfatter
    ved Autophagy Research Group ved UiT Norges arktiske universitet

Andreas Brech

  • Tilknyttet:
    Forfatter
    ved Seksjon for molekylær cellebiologi ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Senter for kreftcelle-reprogrammering ved Universitetet i Oslo
Aktiv cristin-person

Harald Alfred Stenmark

Bidragsyterens navn vises på dette resultatet som Harald Stenmark
  • Tilknyttet:
    Forfatter
    ved Seksjon for molekylær cellebiologi ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Senter for kreftcelle-reprogrammering ved Universitetet i Oslo
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