Cristin-resultat-ID: 1622770
Sist endret: 26. februar 2019, 10:01
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

Short-term cortisol exposure alters cardiac hypertrophic and non-hypertrophic signalling in a time-dependent manner in rainbow trout

Bidragsytere:
  • Karoline Sletbak Nørstrud
  • Marco Vindas
  • Göran Erik Nilsson og
  • Ida Beitnes Johansen

Tidsskrift

Biology Open
ISSN 2046-6390
e-ISSN 2046-6390
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Volum: 7
Hefte: 12
Sider: 1 - 9
Artikkelnummer: bio037853
Open Access

Importkilder

Scopus-ID: 2-s2.0-85057849393

Beskrivelse Beskrivelse

Tittel

Short-term cortisol exposure alters cardiac hypertrophic and non-hypertrophic signalling in a time-dependent manner in rainbow trout

Sammendrag

Cardiac disease is a growing concern in farmed animals, and stress has been implicated as a factor for myocardial dysfunction and mortality in commercial fish rearing. We recently showed that the stress hormone cortisol induces pathological cardiac remodelling in rainbow trout. Wild and farmed salmonids are exposed to fluctuations and sometimes prolonged episodes of increased cortisol levels. Thus, studying the timeframe of cortisol-induced cardiac remodelling is necessary to understand its role in the pathogenesis of cardiovascular disease in salmonids. We here establish that 3 weeks of cortisol exposure is sufficient to increase relative ventricular mass (RVM) by 20% in rainbow trout. Moreover, increased RVMs are associated with altered expression of hypertrophic and non-hypertrophic remodelling markers. Further, we characterised the time course of cortisol-induced cardiac remodelling by feeding rainbow trout cortisol-containing feed for 2, 7 and 21 days. We show that the effect of cortisol on expression of hypertrophic and non-hypertrophic remodelling markers is time-dependent and in some cases acute. Our data indicate that short-term stressors and life cycle transitions associated with elevated cortisol levels can potentially influence hypertrophic and non-hypertrophic remodelling of the trout heart.

Bidragsytere

Karoline Sletbak Nørstrud

  • Tilknyttet:
    Forfatter
    ved Institutt for biovitenskap ved Universitetet i Oslo

Marco Vindas

  • Tilknyttet:
    Forfatter
    ved Institutt for biovitenskap ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet

Göran Erik Nilsson

  • Tilknyttet:
    Forfatter
    ved Institutt for biovitenskap ved Universitetet i Oslo

Ida Beitnes Johansen

  • Tilknyttet:
    Forfatter
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Institutt for biovitenskap ved Universitetet i Oslo
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