Cristin-resultat-ID: 1628954
Sist endret: 4. januar 2019, 10:11
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

Associations between C-reactive protein levels and cognition during the first 6 months after acute psychosis

Bidragsytere:
  • Farivar Fathian
  • Else-Marie Løberg
  • Rolf Gjestad
  • Vidar Martin Steen
  • Rune Andreas Kroken
  • Hugo A Jørgensen
  • mfl.

Tidsskrift

Acta Neuropsychiatrica
ISSN 0924-2708
e-ISSN 1601-5215
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Publisert online: 2018
Sider: 1 - 10

Importkilder

Scopus-ID: 2-s2.0-85056148740

Beskrivelse Beskrivelse

Tittel

Associations between C-reactive protein levels and cognition during the first 6 months after acute psychosis

Sammendrag

Objective: Inverse relationships between the C-reactive protein (CRP) levels and cognitive performance in acute psychosis have been demonstrated. We aimed to investigate how the serum level and initial change of CRP in acutely admitted patients with psychosis was correlated with cognitive performance during a 6-months follow-up period. Methods: The study is part of a pragmatic, randomized trial comparing four different second-generation antipsychotic drugs, and consists of 208 acute phase patients recruited at admittance for psychosis. This study reports data for all groups collectively, and does not compare treatment groups. Measurements of CRP and cognitive performance were conducted at baseline (T1) and after 4 weeks on average after inclusion (T2). Cognition was also assessed after 3 months (T3) and 6 months (T4) of follow-up. Results: Global cognition improved during the follow-up period of 6 months, especially in the T1–T2 interval. The different cognitive subdomains showed different time-dependent profiles of improvement, with memory and attention improving significantly also in the later phases. Reduction of the CRP level during the initial follow-up interval (T1–T2) was associated with increased overall cognitive performance in the T2–T4 interval, but not in the T1–T2 interval. For the cognitive subdomains, we found an inverse association between change in CRP level and verbal abilities (T2–T4 interval), and attention (T2–T3 interval). Conclusion: These findings indicate that initial changes in the serum level of CRP in the acute phase of psychosis may predict cognitive function in later phases of the disease.

Bidragsytere

Farivar Fathian

  • Tilknyttet:
    Forfatter
    ved NKS O​laviken Alderspsykiatriske sykehus​ ved Private ideelle i Helse Vest

Else-Marie Løberg

  • Tilknyttet:
    Forfatter
    ved Institutt for klinisk psykologi ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved Avdeling for rusmedisin ved Helse Bergen HF - Haukeland universitetssykehus
  • Tilknyttet:
    Forfatter
    ved Divisjon psykisk helsevern ved Helse Bergen HF - Haukeland universitetssykehus

Rolf Gjestad

  • Tilknyttet:
    Forfatter
    ved Divisjon psykisk helsevern ved Helse Bergen HF - Haukeland universitetssykehus

Vidar Martin Steen

  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 2 ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved Senter for Medisinsk genetikk og molekylærmedisin ved Helse Bergen HF - Haukeland universitetssykehus

Rune Andreas Kroken

  • Tilknyttet:
    Forfatter
    ved Divisjon psykisk helsevern ved Helse Bergen HF - Haukeland universitetssykehus
  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 1 ved Universitetet i Bergen
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