Cristin-resultat-ID: 1664274
Sist endret: 6. mai 2019, 17:30
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder

Bidragsytere:
  • Michael J. McCarthy
  • Heather Wei
  • Caroline M. Nievergelt
  • Andrea Stautland
  • Adam X. Maihofer
  • David K Welsh
  • mfl.

Tidsskrift

Neuropsychopharmacology
ISSN 0893-133X
e-ISSN 1740-634X
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Publisert online: 2018
Trykket: 2019
Volum: 44
Hefte: 3
Sider: 620 - 628
Open Access

Importkilder

Scopus-ID: 2-s2.0-85057453787

Beskrivelse Beskrivelse

Tittel

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder

Sammendrag

Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs. evening preference (chronotype) as a dimension of circadian rhythm function in 193 Li-R and Li-NR BD patients. From a subset of 59 patients, we measured circadian rhythms in fibroblasts longitudinally over 5 days using a bioluminescent reporter (Per2-luc). We then estimated circadian rhythm parameters (amplitude, period, phase) and the pharmacological effects of lithium on rhythms in cells from Li-R and Li-NR donors. Compared to Li-NRs, Li-Rs showed a difference in chronotype, with higher levels of morningness. Evening chronotype was associated with increased mood symptoms at baseline, including depression, mania, and insomnia. Cells from Li-R patients were more likely to exhibit a short circadian period, a linear relationship between period and phase, and period shortening effects of lithium. Common genetic variation in the IP3 signaling pathway may account for some of the individual differences in the effects of lithium on cellular rhythms. We conclude that circadian rhythms may influence response to lithium in maintenance treatment of BD.

Bidragsytere

Michael J. McCarthy

  • Tilknyttet:
    Forfatter
    ved San Diego State University

Heather Wei

  • Tilknyttet:
    Forfatter
    ved USA

Caroline M. Nievergelt

  • Tilknyttet:
    Forfatter
    ved University of California, San Diego

Andrea Stautland

  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 1 ved Universitetet i Bergen

Adam X. Maihofer

  • Tilknyttet:
    Forfatter
    ved University of California, San Diego
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