Cristin-resultat-ID: 1680854
Sist endret: 26. februar 2019 15:12
Resultat
Doktorgradsavhandling
2018

Poly- and perfluoroalkyl substances (PFASs): from external exposure to human blood

Bidragsytere:
  • Somrutai Poothong

Utgiver/serie

Utgiver

Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Oslo

Serie

Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo.
ISSN 1501-7710
NVI-nivå 0

Om resultatet

Doktorgradsavhandling
Publiseringsår: 2018
Volum: 2018
Hefte: 2043

Klassifisering

Fagfelt (NPI)

Fagfelt: Kjemi
- Fagområde: Realfag og teknologi

Finansiering

  • EU
    Prosjektkode: 316665
  • Norges forskningsråd
    Prosjektkode: 236502

Beskrivelse Beskrivelse

Tittel

Poly- and perfluoroalkyl substances (PFASs): from external exposure to human blood

Sammendrag

This thesis contributed to the field of human exposure to environmental pollutants called poly- and perfluoroalkyl substances (PFASs). Daily intakes of PFASs via ingestion, inhalation, and dermal absorption were estimated and compared to the internal doses. Overall, diet contributed most to the daily intake of PFASs, followed by house dust, indoor air, and dermal absorption, but some variations were observed on an individual basis. Significant associations between concentrations of PFASs measured in serum, and estimated intakes based on direct and indirect (precursor) exposure were observed. Measured serum concentrations and modelled serum concentrations based on external exposure estimates were in the same order of magnitude. The estimated daily intakes of PFASs in this study were lower than the health-based guidance values. Also, in this study, analytical methods have been developed and validated for the determinations of a broad range of PFASs in serum, plasma, whole blood, dried blood spot, and hand wipes. This study underlines the importance of performing studies considering multiple exposure pathways on an individual basis.

Bidragsytere

Somrutai Poothong

  • Tilknyttet:
    Forfatter
    ved Kjemisk institutt ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Avdeling for miljøeksponering og -epidemiologi ved Folkehelseinstituttet

Line Småstuen Haug

  • Tilknyttet:
    Veileder
    ved Avdeling for miljøeksponering og -epidemiologi ved Folkehelseinstituttet

Cathrine Thomsen

  • Tilknyttet:
    Veileder
    ved Avdeling for miljøeksponering og -epidemiologi ved Folkehelseinstituttet

Elsa Lundanes

  • Tilknyttet:
    Veileder
    ved Seksjon for kjemisk livsvitenskap - biomolekyler, bio-inspirerte materialer og bioanalytisk kjemi ved Universitetet i Oslo
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