Cristin-resultat-ID: 1686822
Sist endret: 26. mars 2019, 20:19
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

MicroRNA Networks in Breast Cancer Cells

Bidragsytere:
  • Andliena Tahiri
  • Miriam Ragle Aure og
  • Vessela N. Kristensen

Tidsskrift

Methods in molecular biology
ISSN 1064-3745
e-ISSN 1940-6029
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Publisert online: 2018
Trykket: 2018
Volum: 1711
Sider: 55 - 81

Beskrivelse Beskrivelse

Tittel

MicroRNA Networks in Breast Cancer Cells

Sammendrag

A variety of molecular techniques can be used in order to unravel the molecular composition of cells. In particular, the microarray technology has been used to identify novel biomarkers that may be useful in the diagnosis, prognosis, or treatment of cancer. The microarray technology is ideal for biomarker discovery as it allows for the screening of a large number of molecules at once. In this review, we focus on microRNAs (miRNAs) which are key molecules in cells and regulate gene expression post-transcriptionally. miRNAs are small, single-stranded RNA molecules that bind to complementary mRNAs. Binding of miRNAs to mRNAs leads either to degradation, or translational inhibition of the target mRNA. Roughly one third of all the mRNAs are postulated to be regulated by miRNAs. miRNAs are known to be deregulated in different types of cancer, including breast cancer, and it has been demonstrated that deregulation of several miRNAs can be used as biological markers in cancer. miRNA expression can for example discriminate between normal, benign and malignant breast tissue, and between different breast cancer subtypes. In the post-genomic era, an important task of molecular biology is to understand gene regulation in the context of biological networks. Because miRNAs have such a pronounced role in cells, it is pivotal to understand the mechanisms that underlie their control, and to identify how miRNAs influence cancer development and progression.

Bidragsytere

Andliena Tahiri

  • Tilknyttet:
    Forfatter
    ved Avdeling for klinisk molekylærbiologi og laboratoriefag ved Akershus universitetssykehus HF

Miriam Ragle Aure

  • Tilknyttet:
    Forfatter
    ved Seksjon for kreftgenetikk ved Oslo universitetssykehus HF

Vessela N. Kristensen

  • Tilknyttet:
    Forfatter
    ved Avdeling for klinisk molekylærbiologi og laboratoriefag ved Akershus universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Seksjon for kreftgenetikk ved Oslo universitetssykehus HF
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