Cristin-resultat-ID: 1730538
Sist endret: 19. oktober 2019, 17:55
NVI-rapporteringsår: 2019
Resultat
Vitenskapelig artikkel
2019

Waxholm Space atlas of the rat brain auditory system: Three-dimensional delineations based on structural and diffusion magnetic resonance imaging

Bidragsytere:
  • Kirsten Kjelsberg Osen
  • Jala Imad
  • Arvind Eirik Wennberg
  • Eszter Agnes Papp og
  • Trygve Brauns Leergaard

Tidsskrift

NeuroImage
ISSN 1053-8119
e-ISSN 1095-9572
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2019
Publisert online: 2019
Trykket: 2019
Volum: 199
Sider: 38 - 56
Open Access

Importkilder

Scopus-ID: 2-s2.0-85066168733

Klassifisering

Vitenskapsdisipliner

Medisinsk teknologi

HRCS

  • Helsekategori: 13 - Nevrologisk
    Aktivitet: 1 - Underbyggende Forskning

Beskrivelse Beskrivelse

Tittel

Waxholm Space atlas of the rat brain auditory system: Three-dimensional delineations based on structural and diffusion magnetic resonance imaging

Sammendrag

The mammalian auditory system comprises a complex network of brain regions. Interpretations and comparisons of experimental results from this system depend on appropriate anatomical identification of auditory structures. The Waxholm Space (WHS) atlas of the Sprague Dawley rat brain (Papp et al., Neuroimage 97:374-86, 2014) is an open access, three-dimensional reference atlas defined in an ex-vivo magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) volume. Version 2.0 of the atlas (Kjonigsen et al., Neuroimage 108:441-9, 2015) includes detailed delineations of the hippocampus and several major subcortical regions, but only few auditory structures. To amend this, we have delineated the complete ascending auditory system from the cochlea to the cerebral cortex. 40 new brain structure delineations have been added, and the delineations of 10 regions have been revised based on the interpretation of image features in the WHS rat brain MRI/DTI volumes. We here describe and validate the new delineations in relation to corresponding cell- and myelin-stained histological sections and previous literature. We found it possible to delineate all main regions and the majority of subregions and fibre tracts of the ascending auditory pathway, apart from the auditory cortex, for which delineations were extrapolated from a conventional two-dimensional atlas. By contrast, only parts of the descending pathways were discernible in the template. Version 3.0 of the atlas, with altogether 118 anatomical delineations, is shared via the NeuroImaging Tools and Resources Collaboratory (www.nitrc.org).

Bidragsytere

Kirsten Osen

Bidragsyterens navn vises på dette resultatet som Kirsten Kjelsberg Osen
  • Tilknyttet:
    Forfatter
    ved Nevrale systemer ved Universitetet i Oslo

Jala Imad

  • Tilknyttet:
    Forfatter
    ved Nevrale systemer ved Universitetet i Oslo

Arvind Eirik Wennberg

  • Tilknyttet:
    Forfatter
    ved Nevrale systemer ved Universitetet i Oslo

Eszter Agnes Papp

  • Tilknyttet:
    Forfatter
    ved Nevrale systemer ved Universitetet i Oslo

Trygve Brauns Leergaard

  • Tilknyttet:
    Forfatter
    ved Seksjon for anatomi ved Universitetet i Oslo
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