Benefits of higher resistance‐training volume are related to ribosome biogenesis

Abstract Resistance-exercise volume is a determinant of training outcomes. However not all individuals respond in a dose-dependent fashion. In this study, 34 healthy individuals (males n = 16, 23.6 (4.1) years; females n = 18, 22.0 (1.3) years) performed moderate- (3 sets per exercise, MOD) and low-volume (1 set, LOW) resistance training in a contralateral fashion for 12 weeks (2–3 sessions per week). Muscle cross-sectional area (CSA) and strength were assessed at Weeks 0 and 12, along with biopsy sampling (m. vastus lateralis). Muscle biopsies were alsosampled before and 1 h after the fifth session (Week 2). MOD resulted in larger increases in muscleCSA (5.2 (3.8)% versus 3.7 (3.7)%, P