Cristin-resultat-ID: 1808687
Sist endret: 23. februar 2021, 12:09
NVI-rapporteringsår: 2020
Resultat
Vitenskapelig oversiktsartikkel/review
2020

Arsenic toxicity: Molecular targets and therapeutic agents

Bidragsytere:
  • Valeria Marina Nurchi
  • Aleksandra Buha Djordjevic
  • Guido Crisponi
  • Jan Alexander
  • Geir Bjørklund og
  • Jan Aaseth

Tidsskrift

Biomolecules
ISSN 2218-273X
e-ISSN 2218-273X
NVI-nivå 1

Om resultatet

Vitenskapelig oversiktsartikkel/review
Publiseringsår: 2020
Publisert online: 2020
Volum: 10
Hefte: 2
Artikkelnummer: 235
Open Access

Importkilder

Scopus-ID: 2-s2.0-85079082895

Beskrivelse Beskrivelse

Tittel

Arsenic toxicity: Molecular targets and therapeutic agents

Sammendrag

High arsenic (As) levels in food and drinking water, or under some occupational conditions, can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to unacceptable amounts of As through drinking water and food. Highly exposed individuals may develop acute, subacute, or chronic signs of poisoning, characterized by skin lesions, cardiovascular symptoms, and in some cases, multi-organ failure. Inorganic arsenite(III) and organic arsenicals with the general formula R-As2+ are bound tightly to thiol groups, particularly to vicinal dithiols such as dihydrolipoic acid (DHLA), which together with some seleno-enzymes constitute vulnerable targets for the toxic action of As. In addition, R-As2+-compounds have even higher affinity to selenol groups, e.g., in thioredoxin reductase that also possesses a thiol group vicinal to the selenol. Inhibition of this and other ROS scavenging seleno-enzymes explain the oxidative stress associated with arsenic poisoning. The development of chelating agents, such as the dithiols BAL (dimercaptopropanol), DMPS (dimercapto-propanesulfonate) and DMSA (dimercaptosuccinic acid), took advantage of the fact that As had high affinity towards vicinal dithiols. Primary prevention by reducing exposure of the millions of people exposed to unacceptable As levels should be the prioritized strategy. However, in acute and subacute and even some cases with chronic As poisonings chelation treatment with therapeutic dithiols, in particular DMPS appears promising as regards alleviation of symptoms. In acute cases, initial treatment with BAL combined with DMPS should be considered.

Bidragsytere

Valeria Marina Nurchi

  • Tilknyttet:
    Forfatter
    ved Università degli Studi di Cagliari

Aleksandra Buha Djordjevic

  • Tilknyttet:
    Forfatter
    ved University of Belgrade

Guido Crisponi

  • Tilknyttet:
    Forfatter
    ved Università degli Studi di Cagliari

Jan Alexander

  • Tilknyttet:
    Forfatter
    ved Smittevern ved Folkehelseinstituttet

Geir Bjørklund

  • Tilknyttet:
    Forfatter
    ved Council For Nutritional And Environmental Medicine
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