Cristin-resultat-ID: 1810763
Sist endret: 23. mai 2020 17:03
NVI-rapporteringsår: 2020
Resultat
Vitenskapelig artikkel
2020

The effect of blood pressure on cognitive performance. An 8-year follow-up of the Tromsø Study, comprising people aged 45–74 Years

Bidragsytere:
  • Knut Hestad
  • Knut Engedal
  • Henrik Schirmer og
  • Bjørn Heine Strand

Tidsskrift

Frontiers in Psychology
ISSN 1664-1078
e-ISSN 1664-1078
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2020
Publisert online: 2020
Volum: 11:607
Sider: 1 - 11
Open Access

Importkilder

Scopus-ID: 2-s2.0-85084258902

Beskrivelse Beskrivelse

Tittel

The effect of blood pressure on cognitive performance. An 8-year follow-up of the Tromsø Study, comprising people aged 45–74 Years

Sammendrag

Background: The relationship between blood pressure (BP) and cognition is complex were age appears to be an intervening variable. High and low BP have been associated with cognitive deficits as part of the aging process, but more studies are needed, especially in more recent birth cohorts. Methods: The study sample comprised 4,465 participants, with BP measured at baseline in the Tromsø Study, Wave 6 in 2007–2008 (T0), and cognition assessed at follow-up 8 years later, in 2015–2016 in Tromsø Study 7 (T1). Age at T0 was 45–74 years, and at T1 it was 53–82 years. Cognition was assessed with three tests: The Mini Mental State Examination (MMSE), the Digit Symbol Test, and the Twelve-word Test. The associations between BP and cognition were examined specifically for age and sex using linear regression analysis adjusted for baseline BP medication use, education and body mass index (kg/m2). Results: BP was associated with cognition at the 8-year follow-up, but the association differed according to age and sex. In men, higher systolic blood pressure (SBP) and diastolic blood pressure (DBP) at a young age (45–55 years of age) was associated with poorer cognition; the association was reversed at older ages, especially for those above 65 years of age. In women, the associations were generally weaker than for men, and sometimes in the opposite direction: For women, a higher SBP was associated with better cognition at a younger age and higher SBP poorer cognition at older ages – perhaps due to an age delay in women compared to men. Digit Symbol Test results correlated best with BP in a three-way interaction: BP by age by sex was significant for both SBP (p = 0.005) and DBP (p = 0.005). Conclusion: Increased SBP and DBP at the younger age was clearly associated with poorer cognitive function in men 8 years later; in women the associations were weaker and sometimes in the opposite direction. Our findings clearly indicate that interactions between age and sex related to BP can predict cognitive performance over time. Men and women have different age trajectories regarding the influence of BP on cognition.

Bidragsytere

Aktiv cristin-person

Knut Hestad

  • Tilknyttet:
    Forfatter
    ved Institutt for helse- og sykepleievitenskap ved Høgskolen i Innlandet
  • Tilknyttet:
    Forfatter
    ved Div Psykisk helsevern ved Sykehuset Innlandet HF

Knut Arne Engedal

Bidragsyterens navn vises på dette resultatet som Knut Engedal
  • Tilknyttet:
    Forfatter
    ved Nasjonal kompetansetjeneste for aldring og helse ved Sykehuset i Vestfold HF
Aktiv cristin-person

Henrik Schirmer

  • Tilknyttet:
    Forfatter
    ved Hjertemedisinsk avdeling ved Akershus universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Klinikk for indremedisin og laboratoriefag ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Institutt for klinisk medisin ved UiT Norges arktiske universitet
Aktiv cristin-person

Bjørn Heine Strand

  • Tilknyttet:
    Forfatter
    ved Avdeling for kroniske sykdommer og aldring ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved Nasjonal kompetansetjeneste for aldring og helse ved Sykehuset i Vestfold HF
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