Cristin-resultat-ID: 1825260
Sist endret: 21. februar 2021, 23:06
NVI-rapporteringsår: 2020
Resultat
Vitenskapelig artikkel
2020

The association of PTSD symptom severity with amygdala nuclei volumes in traumatized youths

Bidragsytere:
  • Olga Therese Ousdal
  • Anne Marita Milde
  • Gertrud Sofie Hafstad
  • Erlend Hodneland
  • Grete Dyb
  • Alexander R. Craven
  • mfl.

Tidsskrift

Translational Psychiatry
ISSN 2158-3188
e-ISSN 2158-3188
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2020
Publisert online: 2020
Volum: 10:288
Sider: 1 - 10
Open Access

Importkilder

Scopus-ID: 2-s2.0-85089512182

Beskrivelse Beskrivelse

Tittel

The association of PTSD symptom severity with amygdala nuclei volumes in traumatized youths

Sammendrag

The amygdala is a core component in neurobiological models of stress and stress-related pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have reported increased amygdala activity following traumatic stress exposure and in PTSD, the findings regarding amygdala volume have been mixed. One reason for these mixed findings may be that the amygdala has been considered as a homogenous entity, while it in fact consists of several nuclei with unique cellular and connectivity profiles. Here, we investigated amygdala nuclei volumes of the basolateral and the centrocorticomedial complex in relation to PTSD symptom severity in 47 young survivors from the 2011 Norwegian terror attack 24–36 months post-trauma. PTSD symptoms were assessed 4–5, 14–15 and 24–36 months following the trauma. We found that increased PTSD symptom severity 24–36 months post-trauma was associated with volumetric reductions of all basolateral as well as the central and the medial nuclei. However, only the lateral nucleus was associated with longitudinal symptom development, and mediated the association between 4–5 months and 24–36 months post-trauma symptoms. The results suggest that the amygdala nuclei may be differentially associated with cross-sectional and longitudinal measures of PTSD symptom severity. As such, investigations of amygdala total volume may not provide an adequate index of the association between amygdala and stress-related mental illness.

Bidragsytere

Olga Therese Ousdal

  • Tilknyttet:
    Forfatter
    ved Radiologisk avdeling ved Helse Bergen HF - Haukeland universitetssykehus
Aktiv cristin-person

Anne Marita Milde

  • Tilknyttet:
    Forfatter
    ved Institutt for biologisk og medisinsk psykologi ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved NORCE Helse og samfunn ved NORCE Norwegian Research Centre AS

Gertrud Sofie Hafstad

  • Tilknyttet:
    Forfatter
    ved Nasjonalt kunnskapssenter om vold og traumatisk stress

Erlend Hodneland

  • Tilknyttet:
    Forfatter
    ved NORCE Energi og teknologi ved NORCE Norwegian Research Centre AS

Grete Anita Dyb

Bidragsyterens navn vises på dette resultatet som Grete Dyb
  • Tilknyttet:
    Forfatter
    ved Enhet barne- og ungdomspsykiatri ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Nasjonalt kunnskapssenter om vold og traumatisk stress
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