Cristin-resultat-ID: 1836411
Sist endret: 1. oktober 2021, 22:41
NVI-rapporteringsår: 2020
Resultat
Vitenskapelig artikkel
2020

Characteristics of pulmonary multidrug-resistant tuberculosis patients in Tigray Region, Ethiopia: A cross-sectional study.

Bidragsytere:
  • Letemichael Negash Welekidan
  • Eystein Skjerve
  • Tsehaye Asmelash Dejene
  • Mengistu Welday Gebremichael
  • Ola Brønstad Brynildsrud
  • Angelika Agdestein
  • mfl.

Tidsskrift

PLOS ONE
ISSN 1932-6203
e-ISSN 1932-6203
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2020
Volum: 15
Hefte: 8
Artikkelnummer: e0236362
Open Access

Importkilder

Scopus-ID: 2-s2.0-85089537261

Beskrivelse Beskrivelse

Tittel

Characteristics of pulmonary multidrug-resistant tuberculosis patients in Tigray Region, Ethiopia: A cross-sectional study.

Sammendrag

Background: Tuberculosis (TB) is among the top 10 causes of mortality and the first killer among infectious diseases worldwide. One of the factors fuelling the TB epidemic is the global rise of multidrug resistant TB (MDR-TB). The aim of this study was to determine the magnitude and factors associated with MDR-TB in the Tigray Region, Ethiopia. Method: This study employed a facility-based cross-sectional study design, which was conducted between July 2018 and August 2019. The inclusion criteria for the study participants were GeneXpert-positive who were not under treatment for TB, PTB patients' ≥15 years of age and who provided written informed consent. A total of 300 participants were enrolled in the study, with a structured questionnaire used to collect data on clinical, sociodemographic and behavioral factors. Sputum samples were collected and processed for acid-fast bacilli staining, culture and drug susceptibility testing. Drug susceptibility testing was performed using a line probe assay. Logistic regression was used to analyze associations between outcome and predictor variables. Results: The overall proportion of MDR-TB was 16.7% (11.6% and 32.7% for new and previously treated patients, respectively). Of the total MDR-TB isolates, 5.3% were pre-XDR-TB. The proportion of MDR-TB/HIV co-infection was 21.1%. A previous history of TB treatment AOR 3.75; 95% CI (0.7-2.24), cigarette smoking AOR 6.09; CI (1.65-2.50) and patients who had an intermittent fever (AOR = 2.54, 95% CI = 1.21-5.4) were strongly associated with MDR-TB development. Conclusions: The magnitude of MDR-TB observed among new and previously treated patients is very alarming, which calls for an urgent need for intervention. The high proportion of MDR-TB among newly diagnosed cases indicates ongoing transmission, which suggests the need for enhanced TB control program performance to interrupt transmission. The increased proportion of MDR-TB among previously treated cases indicates a need for better patient management to prevent the evolution of drug resistance. Assessing the TB control program performance gaps and an optimal implementation of the WHO recommended priority actions for the management of drug-resistant TB, is imperative to help reduce the current high MDR-TB burden in the study region.

Bidragsytere

Letemichael Negash Welekidan

  • Tilknyttet:
    Forfatter
    ved Institutt for parakliniske fag ved Norges miljø- og biovitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Mekelle University

Eystein Skjerve

  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet

Tsehaye Asmelash Dejene

  • Tilknyttet:
    Forfatter
    ved Mekelle University

Mengistu Welday Gebremichael

  • Tilknyttet:
    Forfatter
    ved Mekelle University
Aktiv cristin-person

Ola Brønstad Brynildsrud

  • Tilknyttet:
    Forfatter
    ved Avdeling for metodeutvikling og analyse ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved Institutt for parakliniske fag ved Norges miljø- og biovitenskapelige universitet
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