Cristin-resultat-ID: 1845361
Sist endret: 14. februar 2021 15:29
NVI-rapporteringsår: 2020
Resultat
Vitenskapelig artikkel
2020

Primary versus recurrent surgery for glioblastoma-a prospective cohort study

Bidragsytere:
  • Maja Chava Rubin
  • Lisa Millgård Sagberg
  • Asgeir S Jakola og
  • Ole Solheim

Tidsskrift

Acta Neurochirurgica
ISSN 0001-6268
e-ISSN 0942-0940
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2020
Publisert online: 2020
Open Access

Importkilder

Scopus-ID: 2-s2.0-85092476047

Beskrivelse Beskrivelse

Tittel

Primary versus recurrent surgery for glioblastoma-a prospective cohort study

Sammendrag

Background: There is currently limited evidence for surgery in recurrent glioblastoma (GBM). Our aim was to compare primary and recurrent surgeries, regarding changes in perioperative, generic health-related quality of life (HRQoL), complications, extents of resection and survival. Methods: Between 2007 and 2018, 65 recurrent and 160 primary GBM resections were prospectively enrolled. HRQoL was recorded with EQ-5D 3L preoperatively and at 1 month postoperatively. Median perioperative change in HRQoL and change greater than the minimal clinically important difference (MCID) were assessed. Tumour volume and extent of resection were obtained from pre- and postoperative MRI scans. Survival was assessed from date of surgery. Results: Comparing recurrent surgeries and primary resections, most variables were balanced at baseline, but median age (59 vs. 62, p = 0.005) and median preoperative tumour volume (14.9 vs. 25.3 ml, p = 0.001) were lower in recurrent surgeries. There were no statistically significant differences regarding complication rates, neurological deficits, extents of resection or EQ-5D 3L index values at baseline and at follow-up. Twenty (36.4%) recurrent resections vs. 39 (27.5%) primary resections reported clinically significant deterioration in HRQoL at follow-up. Stratified by clinically significant change in EQ-5D 3L, the survival distributions were not statistically significantly different in either group. Survival was associated with extent of resection (p = 0.015) in recurrent surgeries only. Conclusions: Outcomes after primary and recurrent surgeries were quite similar in our practice. As surgery may prolong life in patients where gross total resection is obtainable with reasonable risk, the indication for surgery in GBM should perhaps not differ that much in primary and recurrent resections.

Bidragsytere

Maja Chava Rubin

  • Tilknyttet:
    Forfatter
    ved Institutt for nevromedisin og bevegelsesvitenskap ved Norges teknisk-naturvitenskapelige universitet

Lisa Millgård Sagberg

  • Tilknyttet:
    Forfatter
    ved Nevroklinikken ved St. Olavs Hospital HF
  • Tilknyttet:
    Forfatter
    ved Institutt for nevromedisin og bevegelsesvitenskap ved Norges teknisk-naturvitenskapelige universitet

Asgeir Store Jakola

Bidragsyterens navn vises på dette resultatet som Asgeir S Jakola
  • Tilknyttet:
    Forfatter
    ved Sahlgrenska Universitetssjukhuset
  • Tilknyttet:
    Forfatter
    ved Sahlgrenska Akademin
Aktiv cristin-person

Ole Solheim

  • Tilknyttet:
    Forfatter
    ved Institutt for nevromedisin og bevegelsesvitenskap ved Norges teknisk-naturvitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Nevroklinikken ved St. Olavs Hospital HF
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