Cristin-resultat-ID: 1852539
Sist endret: 16. februar 2021, 08:49
NVI-rapporteringsår: 2020
Resultat
Vitenskapelig artikkel
2020

Sex differences and tumor blood flow from dynamic susceptibility contrast MRI are associated with treatment response after chemoradiation and long-term survival in rectal cancer

Bidragsytere:
  • Kine Mari Bakke
  • Sebastian Meltzer
  • Endre Grøvik
  • Anne Negård
  • Stein Harald Holmedal
  • Kjell-Inge Gjesdal
  • mfl.

Tidsskrift

Radiology
ISSN 0033-8419
e-ISSN 1527-1315
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2020
Volum: 297
Hefte: 2
Sider: 352 - 360
Open Access

Importkilder

Scopus-ID: 2-s2.0-85090678982

Klassifisering

Vitenskapsdisipliner

Fysikk • Medisinsk teknologi

Emneord

Magnetisk resonans tomografi, MRI • Kreftdiagnostikk

Beskrivelse Beskrivelse

Tittel

Sex differences and tumor blood flow from dynamic susceptibility contrast MRI are associated with treatment response after chemoradiation and long-term survival in rectal cancer

Sammendrag

Sex differences, tumor vascularity, and blood flow seen on multiecho dynamic contrast–based MRI scans enabled prediction of treatment response and overall survival in patients with rectal cancer. Background: MRI is the standard tool for rectal cancer staging. However, more precise diagnostic tests that can assess biologic tumor features decisive for treatment outcome are necessary. Tumor perfusion and hypoxia are two important features; however, no reference methods that measure these exist in clinical use. Purpose: To assess the potential predictive and prognostic value of MRI-assessed rectal cancer perfusion, as a surrogate measure of hypoxia, for local treatment response and survival. Materials and Methods: In this prospective observational cohort study, 94 study participants were enrolled from October 2013 to December 2017 (ClinicalTrials.gov: NCT01816607). Participants had histologically confirmed rectal cancer and underwent routine diagnostic MRI, an extended diffusion-weighted sequence, and a multiecho dynamic contrast agent–based sequence. Predictive and prognostic values of dynamic contrast-enhanced, dynamic susceptibility contrast (DSC), and intravoxel incoherent motion MRI were investigated with response to neoadjuvant treatment, progression-free survival, and overall survival as end points. Secondary objectives investigated potential sex differences in MRI parameters and relationship with lymph node stage. Statistical methods used were Cox regression, Student t test, and Mann-Whitney U test.Results: A total of 94 study participants (mean age, 64 years ± 11 [standard deviation]; 61 men) were evaluated. Baseline tumor blood flow from DSC MRI was lower in patients who had poor local tumor response to neoadjuvant treatment (96 mL/min/100 g ± 33 for ypT2–4, 120 mL/min/100 g ± 21 for ypT0–1; P = .01), shorter progression-free survival (hazard ratio = 0.97; 95% confidence interval: 0.96, 0.98; P

Bidragsytere

Kine Mari Bakke

  • Tilknyttet:
    Forfatter
    ved Kreftavdelingen ved Akershus universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Biofysikk og medisinsk fysikk ved Universitetet i Oslo

Sebastian Meltzer

  • Tilknyttet:
    Forfatter
    ved Kreftavdelingen ved Akershus universitetssykehus HF

Endre Grøvik

  • Tilknyttet:
    Forfatter
    ved Avdeling for diagnostisk fysikk ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Institutt for optometri, radiografi og lysdesign ved Universitetet i Sørøst-Norge

Anne Negård

  • Tilknyttet:
    Forfatter
    ved Klinikk for indremedisin og lab fag ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Bildediagnostisk avdeling ved Akershus universitetssykehus HF

Stein Harald Holmedal

  • Tilknyttet:
    Forfatter
    ved Bildediagnostisk avdeling ved Akershus universitetssykehus HF
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