Cristin-resultat-ID: 1870347
Sist endret: 20. januar 2021, 13:38
NVI-rapporteringsår: 2020
Resultat
Vitenskapelig artikkel
2020

Determinants of cardiorespiratory fitness in very long-term survivors of allogeneic hematopoietic stem cell transplantation: a national cohort study

Bidragsytere:
  • Ole Henrik Myrdal
  • Phoi Phoi Diep
  • Ellen Ruud
  • Lorentz Brinch
  • Richard J Massey
  • Elisabeth Edvardsen
  • mfl.

Tidsskrift

Supportive Care in Cancer
ISSN 0941-4355
e-ISSN 1433-7339
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2020
Open Access

Importkilder

Scopus-ID: 2-s2.0-85089751224

Beskrivelse Beskrivelse

Tittel

Determinants of cardiorespiratory fitness in very long-term survivors of allogeneic hematopoietic stem cell transplantation: a national cohort study

Sammendrag

Purpose: Survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at risk for cardiopulmonary adverse events. Data on long-term effects on cardiorespiratory fitness are limited. To address the gap in knowledge, we aimed to determine peak oxygen uptake (V̇O2peak) and identify associations between cardiorespiratory fitness and clinical characteristics, self-reported physical activity, cardiac, and pulmonary function. Methods: In a nationwide, single-center cross-sectional study, 90 survivors [aged median (range) 35 (17–54) years, 56% females] were examined, 17 (6–26) years after allo-HSCT. Myeloablative conditioning comprised busulfan/cyclophosphamide or cyclophosphamide only. Methods included pulmonary function tests, echocardiography, and cardiopulmonary exercise test. Results: Chronic graft-versus-host disease (cGVHD) was found in 31% of the subjects, of whom 40% had bronchiolitis obliterans syndrome (BOS). Seventy-one percent of the survivors did not meet WHO recommendations for physical activity and 42% were overweight. Reduced gas diffusion (DLCO) and systolic ventricular dysfunction (LVEF) were found in 44% and 31%, respectively. For the group, mean (95% CI), V̇O2peak was 36.4 (34.7–38.0) mL/min/kg [89 (85–93)% of predicted]. V̇O2peak was low at 43%. Cardiopulmonary factors and deconditioning were equally common limitations for exercise. In a multiple linear regression model, low V̇O2peak was associated with low DLCO, low LVEF, BOS, overweight, and inactivity. Conclusion: Half of the survivors had reduced cardiorespiratory fitness median 17 years after allo-HSCT. Cardiopulmonary factors and deconditioning were equally common limitations to exercise. We encourage long-term cardiopulmonary monitoring of allo-HSCT survivors and targeted advice on modifiable lifestyle factors.

Bidragsytere

Ole Henrik Myrdal

  • Tilknyttet:
    Forfatter
    ved Lungeavdelingen ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Lungeavdeling - HLK ved Oslo universitetssykehus HF

Phoi Phoi Diep

  • Tilknyttet:
    Forfatter
    ved Pediatri ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Barnemedisinsk avdeling ved Oslo universitetssykehus HF

Ellen Ruud

  • Tilknyttet:
    Forfatter
    ved Barnemedisinsk avdeling ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Pediatri ved Universitetet i Oslo

Lorentz Brinch

  • Tilknyttet:
    Forfatter
    ved Avdeling for blodsykdommer ved Oslo universitetssykehus HF

Richard J Massey

  • Tilknyttet:
    Forfatter
    ved Kardiologisk avdeling ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Kardiologisk avdeling ved Oslo universitetssykehus HF
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