Cristin-resultat-ID: 1871081
Sist endret: 3. november 2021, 10:24
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Influenza vaccination and risk for cardiovascular events: a nationwide self-controlled case series study

Bidragsytere:
  • Abhijit Sen
  • Inger Johanne Landsjøåsen Bakken
  • Ragna Elise Støre Govatsmark
  • Torunn Varmdal
  • Kaare Harald Bønaa
  • Kenneth Jay Mukamal
  • mfl.

Tidsskrift

BMC Cardiovascular Disorders
ISSN 1471-2261
e-ISSN 1471-2261
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Volum: 21
Hefte: 31
Open Access

Importkilder

Scopus-ID: 2-s2.0-85099199174

Beskrivelse Beskrivelse

Tittel

Influenza vaccination and risk for cardiovascular events: a nationwide self-controlled case series study

Sammendrag

Background US and European guidelines diverge on whether to vaccinate adults who are not at high risk for cardiovascular events against influenza. Here, we investigated the associations between influenza vaccination and risk for acute myocardial infarction, stroke and pulmonary embolism during the 2009 pandemic in Norway, when vaccination was recommended to all adults. Methods Using national registers, we studied all vaccinated Norwegian individuals who suffered AMI, stroke, or pulmonary embolism from May 1, 2009 through September 30, 2010. We defined higher-risk individuals as those using anti-diabetic, anti-obesity, anti-thrombotic, pulmonary or cardiovascular medications (i.e. individuals to whom vaccination was routinely recommended); all other individuals were regarded as having lower-risk. We estimated incidence rate ratios with 95% CI using conditional Poisson regression in the pre-defined risk periods up to 180 days following vaccination compared to an unexposed time-period, with adjustment for season or daily temperature. Results Overall, we observed lower risk for cardiovascular events following influenza vaccination. When stratified by baseline risk, we observed lower risk across all three outcomes in association with vaccination among higher-risk individuals. In this subgroup, relative risks were 0.72 (0.59–0.88) for AMI, 0.77 (0.59–0.99) for stroke, and 0.73 (0.45–1.19) for pulmonary embolism in the period 1–14 days following vaccination when compared to the background period. These associations remained essentially the same up to 180 days after vaccination. In contrast, the corresponding relative risks among subjects not using medications were 4.19 (2.69–6.52), 1.73 (0.91–3.31) and 2.35 (0.78–7.06). Conclusion In this nationwide study, influenza vaccination was associated with overall cardiovascular benefit. This benefit was concentrated among those at higher cardiovascular risk as defined by medication use. In contrast, our results demonstrate no comparable inverse association with thrombosis-related cardiovascular events following vaccination among those free of cardiovascular medications at baseline. These results may inform the risk–benefit balance for universal influenza vaccination.

Bidragsytere

Abhijit Sen

  • Tilknyttet:
    Forfatter
    ved Institutt for samfunnsmedisin og sykepleie ved Norges teknisk-naturvitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Kompetansesenteret Tannhelse Midt ved Tannhelsetjenestens kompetansesentre

Inger Johanne Landsjøåsen Bakken

  • Tilknyttet:
    Forfatter
    ved Senter for fruktbarhet og helse ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved Helsedirektoratet

Ragna Elise Støre Govatsmark

  • Tilknyttet:
    Forfatter
    ved Sentral stab ved St. Olavs Hospital HF
  • Tilknyttet:
    Forfatter
    ved Institutt for samfunnsmedisin og sykepleie ved Norges teknisk-naturvitenskapelige universitet
Aktiv cristin-person

Torunn Varmdal

  • Tilknyttet:
    Forfatter
    ved Sentral stab ved St. Olavs Hospital HF

Kaare Harald Bønaa

  • Tilknyttet:
    Forfatter
    ved Kroniske sykdommers epidemiologi, forskningsgruppe ved UiT Norges arktiske universitet
  • Tilknyttet:
    Forfatter
    ved Institutt for sirkulasjon og bildediagnostikk ved Norges teknisk-naturvitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Klinikk for hjertemedisin ved St. Olavs Hospital HF
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