Cristin-resultat-ID: 1878457
Sist endret: 25. januar 2021, 13:32
NVI-rapporteringsår: 2020
Resultat
Vitenskapelig artikkel
2020

Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix

Bidragsytere:
  • Trine Husøy
  • M.A. Martinez
  • R. P. Sharma
  • V. Kumar
  • Monica Andreassen
  • Amrit Kaur Sakhi
  • mfl.

Tidsskrift

Food and Chemical Toxicology
ISSN 0278-6915
e-ISSN 1873-6351
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2020
Volum: 143
Artikkelnummer: 111510
Open Access

Importkilder

Scopus-ID: 2-s2.0-85087431322

Beskrivelse Beskrivelse

Tittel

Comparison of aggregated exposure to di(2-ethylhexyl) phthalate from diet and personal care products with urinary concentrations of metabolites using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix

Sammendrag

Phthalates are widely used as plasticisers in flexible plastics and containers for food and personal care products (PCPs) and contaminates foods and PCPs. A human biomonitoring (BM) study was performed to study exposure of chemicals from foods and PCPs. For two 24-h periods, adult volunteers (n = 144) in Norway kept diaries on food eaten and usage of PCPs, and collected 24-h urine. Aggregated exposure to di(2-ethylhexyl) phthalate (DEHP) from dietary and PCPs was estimated by Monte-Carlo simulation using Oracle Crystal Ball©. Simulated urinary concentrations using physiologically based pharmacokinetic (PBPK) models were compared with measured urinary metabolites of DEHP, mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP) and mono-2-ethyl 5-carboxypentyl phthalate (MECCP). DEHP exposure from food are approximately 10 times higher than exposure than from PCPs. The main contributors to dietary exposure are dairy, grain, fruits and vegetables, meat and fish. Body lotion contribute most to the exposure of DEHP from PCPs. Forward-dosimetry gives good convergence with 24-h urinary concentrations of simulated and measured BM data. The measured concentration of the MECCP metabolite correlated well with simulated high exposure, while the measured concentrations of MEHP, MEHHP and MEOHP partly overlapped with both simulated low, medium and high metabolite exposure.

Bidragsytere

Trine Husøy

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet

M.A. Martinez

  • Tilknyttet:
    Forfatter
    ved Universitat Rovira i Virgili

R. P. Sharma

  • Tilknyttet:
    Forfatter
    ved Vrije Universiteit Amsterdam

V. Kumar

  • Tilknyttet:
    Forfatter
    ved Universitat Rovira i Virgili

Monica Andreassen

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet
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