Sammendrag
Epstein–Barr virus- (EBV-) induced posttransplantation lymphoproliferative disease (PTLD) is a life-threatening complication
following allogeneic stem cell transplantation. *e main risk factor is anti-thymocyte globulin (ATG). Patients who fail first-line
treatment with rituximab have a poor prognosis. *ough adoptive transfer of EBV-specific T cells is a potentially effective option,
it is not readily available. In this case report, the patient developed PTLD following transplantation for aplastic anemia using ATG
as part of the conditioning. He failed rituximab treatment and developed graft failure. We were aware that the stem cell donor had
a recent EBV infection prior to transplantation, whereas the patient most likely was EBV negative before transplant. We describe
our strategy to meet the patient’s urgent need for EBV-specific Tcells, as well as new hematopoietic stem cells. *e same donor was
used for a second transplant, using peripheral blood stem cells. *e conditioning used was thiotepa/busulfan/fludarabin with a
single dose of cyclophosphamide after transplant as graft-versus-host disease (GVHD) prophylaxis. *e EBV DNA levels fell when
conditioning was started, and have been undetectable since day +15 and remained so till 18 months after transplantation. *e
patient is doing well. *is case reports successful use of cyclophosphamide after transplantation as GVHD prophylaxis, preserving
virus-specific immunity.
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