Cristin-resultat-ID: 1899918
Sist endret: 13. januar 2022, 14:38
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Maternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring hippocampus

Bidragsytere:
  • Oddvar Myhre
  • Karin Elisabeth Zimmer
  • Alexandra Misci Hudecova
  • Kristine Eraker Aasland Hansen
  • Abdolrahman Khezri
  • Hanne Friis Berntsen
  • mfl.

Tidsskrift

Chemosphere
ISSN 0045-6535
e-ISSN 1879-1298
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Volum: 276
Artikkelnummer: 130123
Open Access

Importkilder

Scopus-ID: 2-s2.0-85102309296

Beskrivelse Beskrivelse

Tittel

Maternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring hippocampus

Sammendrag

Male and female mice pups were exposed to a low and high dose of a human relevant mixture of persistent organic pollutants (POPs) during pregnancy and lactation. Most compounds detected in the dams were found in offspring brains. The mice offspring exhibited changed expression of hippocampal genes involved in cognitive function (Adora2a, Auts2, Crlf1, Chrnb2, Gdnf, Gnal, Kcnh3), neuroinflammation (Cd47, Il1a), circadian rhythm (Per1, Clock), redox signalling (Hmox2) and aryl hydrocarbon receptor activation (Cyp1b1). A few genes were differentially expressed in males versus females. Mostly, similar patterns of gene expression changes were observed between the low and high dose groups. Effects on learning and memory function measured in the Barnes maze (not moving, escape latency) were found in the high dose group when combined with moderate stress exposure (air flow from a fan). Mediation analysis indicated adaptation to the effects of exposure since gene expression compensated for learning disabilities (escape latency, walking distance and time spent not moving in the maze). Additionally, random forest analysis indicated that Kcnh3, Gnal, and Crlf1 were the most important genes for escape latency, while Hip1, Gnal and the low exposure level were the most important explanatory factors for passive behaviour (not moving). Altogether, this study showed transfer of POPs to the offspring brains after maternal exposure, modulating the expression level of genes involved in brain function.

Bidragsytere

Oddvar Myhre

  • Tilknyttet:
    Forfatter
    ved Smittevern ved Folkehelseinstituttet

Karin Elisabeth Zimmer

  • Tilknyttet:
    Forfatter
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet

Alexandra Misci Hudecova

  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet

Kristine Eraker Aasland Hansen

  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet

Abdolrahman Khezri

  • Tilknyttet:
    Forfatter
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet
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