Cristin-resultat-ID: 1901335
Sist endret: 17. januar 2022, 14:40
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Risk of miscarriage in women with psychiatric disorders

Bidragsytere:
  • Maria Christine Magnus
  • Alexandra Havdahl
  • Nils-Halvdan Morken
  • Knut-Arne Wensaas
  • Allen J. Wilcox og
  • Siri Eldevik Håberg

Tidsskrift

British Journal of Psychiatry
ISSN 0007-1250
e-ISSN 1472-1465
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Trykket: 2021
Volum: 219
Hefte: 3
Sider: 501 - 506

Importkilder

Scopus-ID: 2-s2.0-85113836981

Beskrivelse Beskrivelse

Tittel

Risk of miscarriage in women with psychiatric disorders

Sammendrag

Background Some psychiatric disorders have been associated with increased risk of miscarriage. However, there is a lack of studies considering a broader spectrum of psychiatric disorders to clarify the role of common as opposed to independent mechanisms. Aims To examine the risk of miscarriage among women diagnosed with psychiatric conditions. Method We studied registered pregnancies in Norway between 2010 and 2016 (n = 593 009). The birth registry captures pregnancies ending in gestational week 12 or later, and the patient and general practitioner databases were used to identify miscarriages and induced abortions before 12 gestational weeks. Odds ratios of miscarriage according to 12 psychiatric diagnoses were calculated by logistic regression. Miscarriage risk was increased among women with bipolar disorders (adjusted odds ratio 1.35, 95% CI 1.26–1.44), personality disorders (adjusted odds ratio 1.32, 95% CI 1.12–1.55), attention-deficit hyperactivity disorder (adjusted odds ratio 1.27, 95% CI 1.21–1.33), conduct disorders (1.21, 95% CI 1.01, 1.46), anxiety disorders (adjusted odds ratio 1.25, 95% CI 1.23–1.28), depressive disorders (adjusted odds ratio 1.25, 95% CI 1.23–1.27), somatoform disorders (adjusted odds ratio 1.18, 95% CI 1.07–1.31) and eating disorders (adjusted odds ratio 1.14, 95% CI 1.08–1.22). The miscarriage risk was further increased among women with more than one psychiatric diagnosis. Our findings were robust to adjustment for other psychiatric diagnoses, chronic somatic disorders and substance use disorders. After mutual adjustment for co-occurring psychiatric disorders, we also observed a modest increased risk among women with schizophrenia spectrum disorders (adjusted odds ratio 1.22, 95% CI 1.03–1.44). Conclusions A wide range of psychiatric disorders were associated with increased risk of miscarriage. The heightened risk of miscarriage among women diagnosed with psychiatric disorders highlights the need for awareness and surveillance of this risk group in antenatal care.

Bidragsytere

Maria Christine Magnus

  • Tilknyttet:
    Forfatter
    ved Senter for fruktbarhet og helse ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved University of Bristol
Aktiv cristin-person

Alexandra Havdahl

  • Tilknyttet:
    Forfatter
    ved University of Bristol
  • Tilknyttet:
    Forfatter
    ved Avdeling for psykiske lidelser ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved Nic Waals Institutt ved Lovisenberg Diakonale Sykehus

Nils-Halvdan Morken

  • Tilknyttet:
    Forfatter
    ved Kvinneklinikken ved Helse Bergen HF - Haukeland universitetssykehus
  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 2 ved Universitetet i Bergen

Knut-Arne Wensaas

  • Tilknyttet:
    Forfatter
    ved NORCE Helse - Allmennmedisin ved NORCE Norwegian Research Centre AS

Allen J. Wilcox

  • Tilknyttet:
    Forfatter
    ved USA
  • Tilknyttet:
    Forfatter
    ved National Institutes of Health
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