Cristin-resultat-ID: 1909051
Sist endret: 10. mai 2021, 08:52
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig oversiktsartikkel/review
2021

Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps

Bidragsytere:
  • Birgitte Lindeman
  • Ylva Johansson
  • Mathilda Andreassen
  • Trine Husøy
  • Hubert Dirven
  • Tim Hofer
  • mfl.

Tidsskrift

Reproductive Toxicology
ISSN 0890-6238
e-ISSN 1873-1708
NVI-nivå 1

Om resultatet

Vitenskapelig oversiktsartikkel/review
Publiseringsår: 2021
Trykket: 2021
Volum: 101
Sider: 93 - 114
Open Access

Importkilder

Scopus-ID: 2-s2.0-85102440893

Beskrivelse Beskrivelse

Tittel

Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps

Sammendrag

There is a worldwide concern on adverse health effects of dietary exposure to acrylamide (AA) due to its presence in commonly consumed foods. AA is formed when carbohydrate rich foods containing asparagine and reducing sugars are prepared at high temperatures and low moisture conditions. Upon oral intake, AA is rapidly absorbed and distributed to all organs. AA is a known human neurotoxicant that can reach the developing foetus via placental transfer and breast milk. Although adverse neurodevelopmental effects have been observed after prenatal AA exposure in rodents, adverse effects of AA on the developing brain has so far not been studied in humans. However, epidemiological studies indicate that gestational exposure to AA impair foetal growth and AA exposure has been associated with reduced head circumference of the neonate. Thus, there is an urgent need for further research to elucidate whether pre- and perinatal AA exposure in humans might impair neurodevelopment and adversely affect neuronal function postnatally. Here, we review the literature with emphasis on the iden-tification of critical knowledge gaps in relation to neurodevelopmental toxicity of AA and its mode of action and we suggest research strategies to close these gaps to better protect the unborn child.

Bidragsytere

Birgitte Lindeman

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet

Ylva Johansson

  • Tilknyttet:
    Forfatter
    ved Stockholms universitet

Mathilda Andreassen

  • Tilknyttet:
    Forfatter
    ved Stockholms universitet

Trine Husøy

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet

Hubert Dirven

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet
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