Cristin-resultat-ID: 1911115
Sist endret: 6. januar 2022, 09:12
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children

Bidragsytere:
  • Grethe Åstrøm Ueland
  • Ralf Kellmann
  • Melissa Davidsen Jørstad
  • Kristin Viste
  • Eystein Sverre Husebye
  • Bjørg Almås
  • mfl.

Tidsskrift

Journal of the Endocrine Society (JES)
ISSN 2472-1972
e-ISSN 2472-1972
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Trykket: 2021
Volum: 5
Hefte: 5
Sider: 1 - 8
Artikkelnummer: bvab033
Open Access

Importkilder

Scopus-ID: 2-s2.0-85107774131

Beskrivelse Beskrivelse

Tittel

Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children

Sammendrag

Background:Diagnosing Cushing syndrome (CS) can be challenging. The 24-hour urine free cortisol (UFC) measurement is considered gold standard. This is a laborious test, de-pendent on correct urine collection. Late-night salivary cortisol is easier and is used as a screening test for CS in adults, but has not been validated for use in children. Objective:To define liquid chromatography tandem mass spectrometry (LC-MS/MS)-based cutoff values for bedtime and morning salivary cortisol and cortisone in children, and validate the results in children with and without CS. Methods:Bedtime and morning salivary samples were collected from 320 healthy chil-dren aged 4 to 16 years. Fifty-four patients from the children’s outpatient obesity clinic and 3 children with pituitary CS were used for validation. Steroid hormones were as-sayed by LC-MS/MS. Cutoff levels for bedtime salivary cortisol and cortisone were de-fined by the 97.5% percentile in healthy subjects. Results:Bedtime cutoff levels for cortisol and cortisone were 2.4 and 12.0 nmol/L, re-spectively. Applying these cutoff levels on the verification cohort, 1 child from the obesity clinic had bedtime salivary cortisol exceeding the defined cutoff level, but normal sal-ivary cortisone. All 3 children with pituitary CS had salivary cortisol and cortisone far above the defined bedtime cutoff levels. Healthy subjects showed a significant decrease in salivary cortisol from early morning to bedtime.

Bidragsytere

Grethe Åstrøm Ueland

  • Tilknyttet:
    Forfatter
    ved Medisinsk klinikk ved Helse Bergen HF - Haukeland universitetssykehus
  • Tilknyttet:
    Forfatter
    ved Hormonlaboratoriet ved Helse Bergen HF - Haukeland universitetssykehus

Ralf Kellmann

  • Tilknyttet:
    Forfatter
    ved Hormonlaboratoriet ved Helse Bergen HF - Haukeland universitetssykehus

Melissa Davidsen Jørstad

  • Tilknyttet:
    Forfatter
    ved Hormonlaboratoriet ved Helse Bergen HF - Haukeland universitetssykehus
  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 2 ved Universitetet i Bergen

Kristin Viste

  • Tilknyttet:
    Forfatter
    ved Hormonlaboratoriet ved Helse Bergen HF - Haukeland universitetssykehus

Eystein Sverre Husebye

  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 2 ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved Medisinsk klinikk ved Helse Bergen HF - Haukeland universitetssykehus
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