Cristin-resultat-ID: 1922991
Sist endret: 21. januar 2022, 14:09
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial

Bidragsytere:
  • Andreas Barratt-Due
  • Inge Christoffer Olsen
  • Katerina Nezvalova-Henriksen
  • Trine Kåsine
  • Fridtjof Lund-Johansen
  • Hedda Benedicte Hoel
  • mfl.

Tidsskrift

Annals of Internal Medicine
ISSN 0003-4819
e-ISSN 1539-3704
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Trykket: 2021
Volum: 174
Hefte: 9
Sider: 1261 - 1269

Importkilder

Scopus-ID: 2-s2.0-85112262857

Beskrivelse Beskrivelse

Tittel

Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial

Sammendrag

Background: New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects of these drugs are not known. Objective: To evaluate the effects of remdesivir and HCQ on all-cause, in-hospital mortality; the degree of respiratory failure and inflammation; and viral clearance in the oropharynx. Design: NOR-Solidarity is an independent, add-on, randomized controlled trial to the WHO Solidarity trial that included biobanking and 3 months of clinical follow-up (ClinicalTrials.gov: NCT04321616). Setting: 23 hospitals in Norway. Patients: Eligible patients were adults hospitalized with confirmed SARS-CoV-2 infection. Intervention: Between 28 March and 4 October 2020, a total of 185 patients were randomly assigned and 181 were included in the full analysis set. Patients received remdesivir (n = 42), HCQ (n = 52), or standard of care (SoC) (n = 87). Measurements: In addition to the primary end point of WHO Solidarity, study-specific outcomes were viral clearance in oropharyngeal specimens, the degree of respiratory failure, and inflammatory variables. Results: No significant differences were seen between treatment groups in mortality during hospitalization. There was a marked decrease in SARS-CoV-2 load in the oropharynx during the first week overall, with similar decreases and 10-day viral loads among the remdesivir, HCQ, and SoC groups. Remdesivir and HCQ did not affect the degree of respiratory failure or inflammatory variables in plasma or serum. The lack of antiviral effect was not associated with symptom duration, level of viral load, degree of inflammation, or presence of antibodies against SARS-CoV-2 at hospital admittance. Limitation: The trial had no placebo group. Conclusion: Neither remdesivir nor HCQ affected viral clearance in hospitalized patients with COVID-19.

Bidragsytere

Andreas Barratt-Due

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF

Inge Christoffer Olsen

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF

Katerina Nezvalova-Henriksen

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Sykehusapotekene i Sør-Øst RHF

Trine Kåsine

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF

Fridtjof Lund-Johansen

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Avdeling for immunologi og transfusjonmedisin ved Oslo universitetssykehus HF
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