Sammendrag
When patented, brand-name antibiotics lose market exclusivity, generics typically enter the
market at lower prices, which may increase consumption of the drug. To examine the effect
of generic market entry on antibiotic consumption in the United States, we conducted an
interrupted time series analysis of the change in the number of prescriptions per month for
antibiotics for which at least one generic entered the US market between 2000 and 2012.
Data were acquired from the IQVIA Xponent database. Thirteen antibiotics were analyzed.
Here, we show that one year after generic entry, the number of prescriptions increased for
five antibiotics (5 to 406%)—aztreonam, cefpodoxime, ciprofloxacin, levofloxacin, ofloxacin
—and decreased for one drug: cefdinir. These changes were sustained two years after.
Cefprozil, cefuroxime axetil and clarithromycin had significant increases in trend, but no
significant level changes. No consistent pattern for antibiotic use following generic entry in
the United States was observed.
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