Cristin-resultat-ID: 1939756
Sist endret: 29. september 2021, 00:21
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas

Bidragsytere:
  • Sandra Ferreyra Vega
  • Thomas Olsson Bontell
  • Alba Corell
  • Anja Smits
  • Asgeir Store Jakola og
  • Helena Carén

Tidsskrift

Clinical Epigenetics
ISSN 1868-7075
e-ISSN 1868-7083
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Volum: 13
Hefte: 1
Sider: 1 - 11
Open Access

Importkilder

Scopus-ID: 2-s2.0-85105158825

Beskrivelse Beskrivelse

Tittel

DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas

Sammendrag

Background DNA methylation profiling has facilitated and improved the classification of a wide variety of tumors of the central nervous system. In this study, we investigated the potential utility of DNA methylation profiling to achieve molecular diagnosis in adult primary diffuse lower-grade glioma (dLGG) according to WHO 2016 classification system. We also evaluated whether methylation profiling could provide improved molecular characterization and identify prognostic differences beyond the classical histological WHO grade together with IDH mutation status and 1p/19q codeletion status. All patients diagnosed with dLGG in the period 2007–2016 from the Västra Götaland region in Sweden were assessed for inclusion in the study. Results A total of 166 dLGG cases were subjected for genome-wide DNA methylation analysis. Of these, 126 (76%) were assigned a defined diagnostic methylation class with a class prediction score ≥ 0.84 and subclass score ≥ 0.50. The assigned methylation classes were highly associated with their IDH mutation status and 1p/19q codeletion status. IDH-wildtype gliomas were further divided into subgroups with distinct molecular features. Conclusion The stratification of the patients by methylation profiling was as effective as the integrated WHO 2016 molecular reclassification at predicting the clinical outcome of the patients. Our study shows that DNA methylation profiling is a reliable and robust approach for the classification of dLGG into molecular defined subgroups, providing accurate detection of molecular markers according to WHO 2016 classification.

Bidragsytere

Sandra Ferreyra Vega

  • Tilknyttet:
    Forfatter
    ved Göteborgs universitet

Thomas Olsson Bontell

  • Tilknyttet:
    Forfatter
    ved Göteborgs universitet
  • Tilknyttet:
    Forfatter
    ved Sahlgrenska Universitetssjukhuset

Alba Corell

  • Tilknyttet:
    Forfatter
    ved Sahlgrenska Universitetssjukhuset
  • Tilknyttet:
    Forfatter
    ved Göteborgs universitet

Anja Smits

  • Tilknyttet:
    Forfatter
    ved Göteborgs universitet
  • Tilknyttet:
    Forfatter
    ved Uppsala universitet

Asgeir Store Jakola

  • Tilknyttet:
    Forfatter
    ved Sahlgrenska Akademin
  • Tilknyttet:
    Forfatter
    ved Nevroklinikken ved St. Olavs Hospital HF
  • Tilknyttet:
    Forfatter
    ved Sahlgrenska Universitetssjukhuset
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