Cristin-resultat-ID: 1942514
Sist endret: 1. oktober 2021, 23:04
Vitenskapelig foredrag

Role of Post-translational Modifications in Antimicrobial Resistance

  • Tone Tonjum


Navn på arrangementet: GLOBVAC Webinar on Communicable Disaeases
Sted: Webinar
Dato fra: 12. januar 2021
Dato til: 12. januar 2021


Arrangørnavn: Norges forskningsråd

Om resultatet

Vitenskapelig foredrag
Publiseringsår: 2021

Beskrivelse Beskrivelse


Role of Post-translational Modifications in Antimicrobial Resistance


Background: The public health challenge of antimicrobial resistance (AMR) is escalating rapidly throughout the world, while the number of effective antimicrobial drugs continues to decrease. Numerous microbial DNA mutations and horizontal gene transfer events that directly cause or contribute to AMR have been identified and thoroughly characterized. Now we are discovering that additional mechanisms, such as macromolecular decorations of proteins, termed post-translational modifications (PTMs), also are implicated in AMR development. Tuberculosis (TB) is one of the top 10 causes of death worldwide. This devastating infectious disease, caused by Mycobacterium tuberculosis (Mtb), was reported to be the cause of 10 million new cases. and 1.5 million deaths in 2019. Methods: Mtb members of lineages 3, 4, 5 and 7 were investigated to better understand the evolution of virulence and AMR. Unique and shared proteomic signatures, as deduced from quantitative bioinformatics analyses of high-resolution mass spectrometry data, were delineated and related to phenotypic traits. Results: The slow-growing Lineage 7 exhibited increased abundance of proteins involved in DNA repair, secretion and the CRISPR/Cas system as compared to the other lineages. MDR strains of lineage 2 had a reduced abundance of proteins involved in DNA repair and CRISPR/Cas. Notably, protein PTMs such as glycosylation and acetylation were found to play a significant role in Mtb adaptive processes and in AMR. Discussion: The study identified several clinically important glycosylated and acetylated proteins that are applicable for diagnostics as well as for drug and vaccine discovery, highly relevant for improved global health in a next-generation setting.


Tone Tønjum

Bidragsyterens navn vises på dette resultatet som Tone Tonjum
  • Tilknyttet:
    ved Avdeling for mikrobiologi ved Oslo universitetssykehus HF
  • Tilknyttet:
    ved Avdeling for mikrobiologi ved Universitetet i Oslo
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