Cristin-resultat-ID: 1946119
Sist endret: 9. februar 2022, 10:55
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

The relationship between directly measured statin adherence, self-reported adherence measures and cholesterol levels in patients with coronary heart disease

Bidragsytere:
  • Oskar Kristiansen
  • Elise Christine Bjørkholen Sverre
  • Kari Peersen
  • Morten Fagerland
  • Erik Gjertsen
  • Lars Gullestad
  • mfl.

Tidsskrift

Atherosclerosis
ISSN 0021-9150
e-ISSN 1879-1484
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Trykket: 2021
Volum: 336
Sider: 23 - 29
Open Access

Importkilder

Scopus-ID: 2-s2.0-85116009326

Beskrivelse Beskrivelse

Tittel

The relationship between directly measured statin adherence, self-reported adherence measures and cholesterol levels in patients with coronary heart disease

Sammendrag

Background and aims: We aimed to determine the relationship between statin adherence measured directly, and by self-report measures and serum cholesterol levels. Methods: Patients prescribed atorvastatin (N = 373) participated in a cross-sectional study 2–36 months after a coronary event. Self-reported adherence included statin adherence the past week, the 8-item Morisky medication adherence scale (MMAS-8), and the Gehi et al. adherence question. Atorvastatin was measured directly in spot blood plasma by a novel liquid chromatography tandem mass-spectrometry method discriminating adherence (0–1 doses omitted) and reduced adherence (≥2 doses omitted). Participants were unaware of the atorvastatin analyses at study participation. Results: Mean age was 63 (SD 9) years and 8% had reduced atorvastatin adherence according to the direct method. In patients classified with reduced adherence by the direct method, 40% reported reduced statin adherence, 32% reported reduced adherence with the MMAS-8 and 22% with the Gehi question. In those adherent by the direct method, 96% also reported high statin adherence, 95% reported high adherence on the MMAS-8 whereas 94% reported high adherence on the Gehi question. Cohen’s kappa agreement score with the direct method was 0.4 for self-reported statin adherence, 0.3 for the Gehi question and 0.2 for the MMAS-8. Adherence determined by the direct method, self-reported statin adherence last week, and the Gehi question was inversely related to LDL-cholesterol levels with a p-value of

Bidragsytere

Oscar Kristiansen

Bidragsyterens navn vises på dette resultatet som Oskar Kristiansen
  • Tilknyttet:
    Forfatter
    ved Avdeling for atferdsmedisin ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Drammen sykehus ved Vestre Viken HF

Elise Christine Bjørkholen Sverre

  • Tilknyttet:
    Forfatter
    ved Drammen sykehus ved Vestre Viken HF
  • Tilknyttet:
    Forfatter
    ved Avdeling for atferdsmedisin ved Universitetet i Oslo

Kari Peersen

  • Tilknyttet:
    Forfatter
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF

Morten Wang Fagerland

Bidragsyterens navn vises på dette resultatet som Morten Fagerland
  • Tilknyttet:
    Forfatter
    ved Biostatistikk, epidemiologi og helseøkonomi (OSS) ved Oslo universitetssykehus HF

Erik Gjertsen

  • Tilknyttet:
    Forfatter
    ved Drammen sykehus ved Vestre Viken HF
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