Cristin-resultat-ID: 1950417
Sist endret: 3. januar 2022, 15:05
NVI-rapporteringsår: 2021
Vitenskapelig oversiktsartikkel/review

Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review

  • Urban Alehagen
  • Trine B. Opstad
  • Jan Alexander
  • Anders Larsson og
  • Jan Aaseth


ISSN 2218-273X
e-ISSN 2218-273X
NVI-nivå 1

Om resultatet

Vitenskapelig oversiktsartikkel/review
Publiseringsår: 2021
Publisert online: 2021
Volum: 11
Hefte: 10
Sider: 1 - 14
Artikkelnummer: 1478
Open Access


Scopus-ID: 2-s2.0-85116455334

Beskrivelse Beskrivelse


Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review


Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center and include, i.a., the enzymes thioredoxin reductases (TXNRD1–3), glutathione peroxidases (GPX1–4 and GPX6) and methionine sulfoxide reductase, involved in immune functions, metabolic homeostasis, and antioxidant defense. Ageing is an inevitable process, which, i.a., involves an imbalance between antioxidative defense and reactive oxygen species (ROS), changes in protein and mitochondrial renewal, telomere attrition, cellular senescence, epigenetic alterations, and stem cell exhaustion. These conditions are associated with mild to moderate inflammation, which always accompanies the process of ageing and age-related diseases. In older individuals, Se, by being a component in protective enzymes, operates by decreasing ROS-mediated inflammation, removing misfolded proteins, decreasing DNA damage, and promoting telomere length. Se-dependent GPX1–4 and TXNRD1–3 directly suppress oxidative stress. Selenoprotein H in the cell nucleus protects DNA, and selenoproteins residing in the endoplasmic reticulum (ER) assist in the removal of misfolded proteins and protection against ER stress. In this review, we highlight the role of adequate Se status for human ageing and prevention of age-related diseases, and further its proposed role in preservation of telomere length in middle-aged and elderly individuals.


Urban Alehagen

  • Tilknyttet:
    ved Linköpings universitet

Trine Baur Opstad

Bidragsyterens navn vises på dette resultatet som Trine B. Opstad
  • Tilknyttet:
    ved Hjertemedisinsk avdeling ved Oslo universitetssykehus HF
  • Tilknyttet:
    ved Universitetet i Oslo

Jan Alexander

  • Tilknyttet:
    ved Avdeling for miljø og helse ved Folkehelseinstituttet

Anders Larsson

  • Tilknyttet:
    ved Uppsala universitet

Jan Olav Aaseth

Bidragsyterens navn vises på dette resultatet som Jan Aaseth
  • Tilknyttet:
    ved Sykehuset Innlandet HF
  • Tilknyttet:
    ved Fakultet for helse- og sosialvitenskap ved Høgskolen i Innlandet
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