Cristin-resultat-ID: 1970863
Sist endret: 12. januar 2022, 13:04
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Clinical and psychological factors in coronary heart disease patients with statin associated muscle side-effects

Bidragsytere:
  • Kari Peersen
  • John Munkhaugen
  • Elise Christine Bjørkholen Sverre
  • Oskar Kristiansen
  • Morten Fagerland
  • Nils Tore Vethe
  • mfl.

Tidsskrift

BMC Cardiovascular Disorders
ISSN 1471-2261
e-ISSN 1471-2261
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Volum: 21
Sider: 1 - 9
Artikkelnummer: 596
Open Access

Importkilder

Scopus-ID: 2-s2.0-85121459097

Beskrivelse Beskrivelse

Tittel

Clinical and psychological factors in coronary heart disease patients with statin associated muscle side-effects

Sammendrag

Background: To compare clinical and psychological factors among patients with self-perceived statin-associated muscle symptoms (SAMS), confirmed SAMS, and refuted SAMS in coronary heart disease patients (CHD). Methods: Data were obtained from a cross-sectional study of 1100 CHD outpatients and a study of 71 CHD outpatients attending a randomized, double-blinded, placebo-controlled, crossover study to test effects of atorvastatin 40 mg/day on muscle symptom intensity. Clinical and psychosocial factors were compared between patients with and without SAMS in the cross-sectional study, and between patients with confirmed SAMS and refuted SAMS in the randomized study. Results: Bilateral, symmetric muscle symptoms in the lower extremities during statin treatment were more prevalent in patients with confirmed SAMS compared to patients with refuted SAMS (75% vs. 41%, p = 0.01) in the randomized study. No significant differences in psychological factors (anxiety, depression, worry, insomnia, type D personality characteristics) were detected between patients with and without self-perceived SAMS in the cross-sectional study, or between patients with confirmed SAMS and refuted SAMS, in the randomized study. Conclusions: Patients with confirmed SAMS more often present with bilateral lower muscle symptoms compared to those with refuted SAMS. Psychological factors were not associated with self-perceived SAMS or confirmed SAMS. A careful pain history and a search for alternative causes of muscle symptoms are likely to promote communication in patients with SAMS, and may reduce the risk for statin discontinuation.

Bidragsytere

Kari Peersen

  • Tilknyttet:
    Forfatter
    ved Avdeling for medisinsk atferdsvitenskap ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF

John Munkhaugen

  • Tilknyttet:
    Forfatter
    ved Avdeling for medisinsk atferdsvitenskap ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Drammen sykehus ved Vestre Viken HF

Elise Christine Bjørkholen Sverre

  • Tilknyttet:
    Forfatter
    ved Drammen sykehus ved Vestre Viken HF
  • Tilknyttet:
    Forfatter
    ved Avdeling for medisinsk atferdsvitenskap ved Universitetet i Oslo

Oskar Kristiansen

  • Tilknyttet:
    Forfatter
    ved Drammen sykehus ved Vestre Viken HF

Morten Wang Fagerland

Bidragsyterens navn vises på dette resultatet som Morten Fagerland
  • Tilknyttet:
    Forfatter
    ved Biostatistikk, epidemiologi og helseøkonomi (OSS) ved Oslo universitetssykehus HF
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