Cristin-resultat-ID: 1972061
Sist endret: 12. mai 2022, 07:57
NVI-rapporteringsår: 2022
Resultat
Vitenskapelig oversiktsartikkel/review
2022

Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics

Bidragsytere:
  • Veronika K. Pettersen
  • Luis Caetano Martha Antunes
  • Antoine Dufour og
  • Marie-Claire Arrieta

Tidsskrift

Computational and Structural Biotechnology Journal
ISSN 2001-0370
e-ISSN 2001-0370
NVI-nivå 1

Om resultatet

Vitenskapelig oversiktsartikkel/review
Publiseringsår: 2022
Publisert online: 2021
Trykket: 2022
Volum: 20
Sider: 274 - 286
Open Access

Beskrivelse Beskrivelse

Tittel

Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics

Sammendrag

Humans have a long-standing coexistence with microorganisms. In particular, the microbial community that populates the human gastrointestinal tract has emerged as a critical player in governing human health and disease. DNA and RNA sequencing techniques that map taxonomical composition and genomic potential of the gut community have become invaluable for microbiome research. However, deriving a biochemical understanding of how activities of the gut microbiome shape host development and physiology requires an expanded experimental design that goes beyond these approaches. In this review, we explore advances in high-throughput techniques based on liquid chromatography–mass spectrometry. These omics methods for the identification of proteins and metabolites have enabled direct characterisation of gut microbiome functions and the crosstalk with the host. We discuss current metaproteomics and metabolomics workflows for producing functional profiles, the existing methodological challenges and limitations, and recent studies utilising these techniques with a special focus on early life gut microbiome.

Bidragsytere

Veronika K. Pettersen

  • Tilknyttet:
    Forfatter
    ved Vert-mikrobe interaksjoner, forskningsgruppe ved UiT Norges arktiske universitet

Luis Caetano Martha Antunes

  • Tilknyttet:
    Forfatter
    ved Fundação Oswaldo Cruz

A Dufour

Bidragsyterens navn vises på dette resultatet som Antoine Dufour
  • Tilknyttet:
    Forfatter
    ved The University of Calgary

Marie-Claire Arrieta

  • Tilknyttet:
    Forfatter
    ved The University of Calgary
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