Cristin-resultat-ID: 1979158
Sist endret: 17. februar 2022, 10:53
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Longitudinal changes in neurometabolite concentrations in the dorsal anterior cingulate cortex after concentrated exposure therapy for obsessive-compulsive disorder

Bidragsytere:
  • Niels T. de Joode
  • Anders Lillevik Thorsen
  • Eline L. Vester
  • Chris Vriend
  • Petra J.W. Pouwels
  • Kristen Hagen
  • mfl.

Tidsskrift

Journal of Affective Disorders
ISSN 0165-0327
e-ISSN 1573-2517
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Trykket: 2022
Volum: 299
Sider: 344 - 352

Importkilder

Scopus-ID: 2-s2.0-85121288928

Beskrivelse Beskrivelse

Tittel

Longitudinal changes in neurometabolite concentrations in the dorsal anterior cingulate cortex after concentrated exposure therapy for obsessive-compulsive disorder

Sammendrag

Abstract Background The dorsal anterior cingulate cortex (dACC) plays an important role in the pathophysiology of obsessive-compulsive disorder (OCD) due to its role in error processing, cognitive control and emotion regulation. OCD patients have shown altered concentrations in neurometabolites in the dACC, particularly Glx (glutamate+glutamine) and tNAA (N-acetylaspartate+N-acetyl-aspartyl-glutamate). We investigated the immediate and prolonged effects of exposure and response prevention (ERP) on these neurometabolites. Methods Glx and tNAA concentrations were measured using magnetic resonance spectroscopy (1H-MRS) in 24 OCD patients and 23 healthy controls at baseline. Patients received concentrated ERP over four days. A subset was re-scanned after one week and three months. Results No Glx and tNAA abnormalities were observed in OCD patients compared to healthy controls before treatment or over time. Patients with childhood or adult onset differed in the change over time in tNAA (F(2,40) = 7.24, ɳ2p= 0.27, p = 0.004): concentrations increased between one week after treatment and follow-up in the childhood onset group (t(39) = -2.43, d = -0.86, p = 0.020), whereas tNAA concentrations decreased between baseline and follow-up in patients with an adult onset (t(42) = 2.78, d = 1.07, p = 0.008). In OCD patients with versus without comorbid mood disorders, lower Glx concentrations were detected at baseline (t(38) = -2.28, d = -1.00, p = 0.028). Glx increased after one week of treatment within OCD patients with comorbid mood disorders (t(30) = -3.09, d = -1.21, p = 0.004). Limitations Our OCD sample size allowed the detection of moderate to large effect sizes only. Conclusion ERP induced changes in neurometabolites in OCD seem to be dependent on mood disorder comorbidity and disease stage rather than OCD itself.

Bidragsytere

Niels Joode

Bidragsyterens navn vises på dette resultatet som Niels T. de Joode
  • Tilknyttet:
    Forfatter
    ved Vrije Universiteit Amsterdam
Aktiv cristin-person

Anders Lillevik Thorsen

  • Tilknyttet:
    Forfatter
    ved Senter for krisepsykologi ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved Divisjon psykisk helsevern ved Helse Bergen HF - Haukeland universitetssykehus

Eline Vester

Bidragsyterens navn vises på dette resultatet som Eline L. Vester
  • Tilknyttet:
    Forfatter
    ved Vrije Universiteit Amsterdam

Chris Vriend

  • Tilknyttet:
    Forfatter
    ved Vrije Universiteit Amsterdam

Petra J.W. Pouwels

  • Tilknyttet:
    Forfatter
    ved Vrije Universiteit Amsterdam
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