Cristin-resultat-ID: 2012495
Sist endret: 28. mars 2022, 11:04
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease

Bidragsytere:
  • Rebecca Ashley Gladstone
  • Lotta Siira
  • Ola Brønstad Brynildsrud
  • Didrik Frimann Vestrheim
  • Paul Turner
  • S.C. Clarke
  • mfl.

Tidsskrift

Vaccine
ISSN 0264-410X
e-ISSN 1873-2518
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Volum: 40
Hefte: 7
Sider: 1054 - 1060
Open Access

Importkilder

Scopus-ID: 2-s2.0-85122325554

Beskrivelse Beskrivelse

Tittel

International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease

Sammendrag

Background: Pneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported in several countries. We aimed to use genomics to establish any international links between them. Methods: Sequence data from ST801-related outbreak isolates from Norway (n = 17), Finland (n = 11) and Northern Ireland (n = 2) were combined with invasive pneumococcal disease surveillance from the respective countries, and ST801-related genomes from an international collection (n = 41 of > 40,000), totalling 106 genomes. Raw data were mapped and recombination excluded before phylogenetic dating. Results: Outbreak isolates were relatively diverse, with up to 100 SNPs (single nucleotide polymorphisms) and a common ancestor estimated around the year 2000. However, 19 Norwegian and Finnish isolates were nearly indistinguishable (0-2 SNPs) with the common ancestor dated around 2017. Conclusion: The total diversity of ST801 within the outbreaks could not be explained by recent transmission alone, suggesting that harsh environmental and associated living conditions reported in the shipyards may facilitate invasion of colonising pneumococci. However, near identical strains in the Norwegian and Finnish outbreaks does suggest that transmission between international shipyards also contributed to those outbreaks. This indicates the need for improved preventative measures in this working population including pneumococcal vaccination.

Bidragsytere

Rebecca Ashley Gladstone

  • Tilknyttet:
    Forfatter
    ved Wellcome Trust Sanger Institute
  • Tilknyttet:
    Forfatter
    ved Probabilistisk inferens laboratorium ved Universitetet i Oslo

Lotta Siira

  • Tilknyttet:
    Forfatter
    ved Terveyden ja hyvinvoinnin laitos
Aktiv cristin-person

Ola Brønstad Brynildsrud

  • Tilknyttet:
    Forfatter
    ved Avdeling for metodeutvikling og analyse ved Folkehelseinstituttet

Didrik Frimann Vestrheim

  • Tilknyttet:
    Forfatter
    ved Avdeling for smittevern og vaksine ved Folkehelseinstituttet

Paul Turner

  • Tilknyttet:
    Forfatter
    ved Kambodsja
  • Tilknyttet:
    Forfatter
    ved University of Oxford
1 - 5 av 21 | Neste | Siste »