Cristin-resultat-ID: 2020413
Sist endret: 14. mars 2023, 14:18
NVI-rapporteringsår: 2022
Resultat
Vitenskapelig artikkel
2022

Antibiotic use in children before, during and after hospitalisation

Bidragsytere:
  • Christian Magnus Thaulow
  • Hege Salvesen Blix
  • Roy Miodini Nilsen
  • Beate Horsberg Eriksen
  • Jannicke Slettli Wathne
  • Dag Berild
  • mfl.

Tidsskrift

Pharmacoepidemiology and Drug Safety
ISSN 1053-8569
e-ISSN 1099-1557
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2022
Publisert online: 2022
Trykket: 2022
Volum: 31
Hefte: 7
Sider: 749 - 757
Open Access

Importkilder

Scopus-ID: 2-s2.0-85128337149

Beskrivelse Beskrivelse

Tittel

Antibiotic use in children before, during and after hospitalisation

Sammendrag

Purpose To investigate ambulatory antibiotic use in children during 1 year before and 1 year after in-hospital antibiotic exposure compared to children from the general population that had not received antibiotics in-hospital. Methods Explorative data-linkage cohort study from Norway of children aged 3 months to 17 years. One group had received antibiotics in-Hospital (H+), and one group had not received antibiotics in-hospital (H-). The H+ group was recruited during admission in 2017. Using the Norwegian Population Registry, 10 children from the H- group were matched with one child from the H+ group according to county of residence, age and sex. We used the Norwegian Prescription Database to register antibiotic use 1 year before and 1 year after the month of hospitalisation. Results Of 187 children in the H+ group, 83 (44%) received antibiotics before hospitalisation compared to 288/1870 (15%) in the H- group, relative risk (RR) 2.88 (95% confidence interval 2.38–3.49). After hospitalisation, 86 (46%) received antibiotics in the H+ group compared to 311 (17%) in the H- group, RR 2.77 (2.30–3.33). Comorbidity-adjusted RR was 2.30 (1.84–2.86) before and 2.25 (1.81–2.79) after hospitalisation. RR after hospitalisation was 2.55 (1.99–3.26) in children 3 months-2 years, 4.03 (2.84–5.71) in children 3–12 years and 2.07 (1.33–3.20) in children 13–17 years. Conclusions Children exposed to antibiotics in-hospital had two to three times higher risk of receiving antibiotics in ambulatory care both before and after hospitalisation. The link between in-hospital and ambulatory antibiotic exposure should be emphasised in future antibiotic stewardship programs.

Bidragsytere

Christian Magnus Thaulow

  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 2 ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved Barneklinikken ved Helse Bergen HF - Haukeland universitetssykehus

Hege Salvesen Blix

  • Tilknyttet:
    Forfatter
    ved Seksjon for farmakologi og farmasøytisk ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Avdeling for legemiddelstatistikk ved Folkehelseinstituttet

Roy Miodini Nilsen

  • Tilknyttet:
    Forfatter
    ved Institutt for helse og funksjon ved Høgskulen på Vestlandet

Beate Horsberg Eriksen

  • Tilknyttet:
    Forfatter
    ved Klinikk Ålesund sjukehus ved Helse Møre og Romsdal HF
  • Tilknyttet:
    Forfatter
    ved MH fakultetsadministrasjon ved Norges teknisk-naturvitenskapelige universitet
Aktiv cristin-person

Jannicke Slettli Wathne

  • Tilknyttet:
    Forfatter
    ved Sjukehusapoteka Vest HF
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