Cristin-resultat-ID: 2021894
Sist endret: 16. februar 2023, 11:56
NVI-rapporteringsår: 2022
Resultat
Vitenskapelig artikkel
2022

Anti-androgenic compounds in breast milk and cryptorchidism among Norwegian boys in the HUMIS birth cohort

Bidragsytere:
  • Bérénice Collet
  • Anteneh Assefa Desalegn
  • Kees Swart
  • Matthijs Naderman
  • Nina Iszatt
  • Hein Stigum
  • mfl.

Tidsskrift

Science of the Total Environment
ISSN 0048-9697
e-ISSN 1879-1026
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2022
Publisert online: 2022
Volum: 803
Artikkelnummer: 149746
Open Access

Importkilder

Scopus-ID: 2-s2.0-85114790120

Beskrivelse Beskrivelse

Tittel

Anti-androgenic compounds in breast milk and cryptorchidism among Norwegian boys in the HUMIS birth cohort

Sammendrag

The prevalence of cryptorchidism has increased over the past decades, yet its origins remain poorly understood. Testis descent is dependent on androgens and likely affected by endocrine disrupting compounds (EDCs), targeting the androgen receptor (AR). We investigated the association between anti-androgenic activity, not derived from natural hormones, in maternal breast milk and impaired testis descent among boys. We performed a case-control study based on 199 breast milk samples from 94 mothers of cryptorchid boys and 105 random non-cryptorchid boys participating in the Norwegian HUMIS (Human Milk Study) cohort. For each participant, apolar, and polar fractions were extracted, and combined to reconstitute a mixture. Anti-androgenic activity was measured in all three fractions using the human cell-based in vitro anti-AR CALUX® assay and expressed in μg of flutamide equivalent, a well-known antiandrogen. Results from fraction analyses were compared among boys with cryptorchidism and controls using multiple logistic regression, controlling for appropriate confounders identified using a directed acyclic graph. Children's daily exposure to anti-androgenic EDCs through breastfeeding was estimated to 78 μg flutamide eq./kg of body weigh/day. The activity was higher in the polar fraction (1.48 ± 1.37 μg flutamide eq./g of milk) mainly representing non-persistent chemicals, in contrast to other fractions. However, the activity in the polar extracts was decreased when in mixtures with the apolar fraction, indicating synergistic interactions. No significant difference in the activity was observed according to cryptorchid status for polar, apolar or mixed breast milk fractions. The study showed anti-androgenic activity in nearly all human milk samples, and at levels higher than the advisory threshold. However, no significant association was observed between cryptorchidism and antiandrogenic activity measured in either polar, apolar, or mixture fractions derived from breast milk.

Bidragsytere

Bérénice Collet

  • Tilknyttet:
    Forfatter
    ved Vrije Universiteit Amsterdam

Anteneh Assefa Desalegn

  • Tilknyttet:
    Forfatter
    ved Seksjon for galenisk farmasi og samfunns ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Avdeling for mattrygghet ved Folkehelseinstituttet

Kees Swart

  • Tilknyttet:
    Forfatter
    ved Nederland

Matthijs Naderman

  • Tilknyttet:
    Forfatter
    ved Nederland
Aktiv cristin-person

Nina Louise Torcelino-Iszatt

Bidragsyterens navn vises på dette resultatet som Nina Iszatt
  • Tilknyttet:
    Forfatter
    ved Avdeling for mattrygghet ved Folkehelseinstituttet
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