Cristin-resultat-ID: 2025889
Sist endret: 13. juni 2022, 12:37
NVI-rapporteringsår: 2022
Resultat
Vitenskapelig artikkel
2022

Reference curves for pediatric endocrinology: leveraging biomarker z-scores for clinical classifications

Bidragsytere:
  • Andre Madsen
  • Bjørg Almås
  • Ingvild Særvold Bruserud
  • Ninnie Helen Bakken Oehme
  • Christopher Sivert Nielsen
  • Mathieu Roelants
  • mfl.

Tidsskrift

Journal of Clinical Endocrinology and Metabolism (JCEM)
ISSN 0021-972X
e-ISSN 1945-7197
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2022
Publisert online: 2022
Sider: 1 - 12
Open Access

Beskrivelse Beskrivelse

Tittel

Reference curves for pediatric endocrinology: leveraging biomarker z-scores for clinical classifications

Sammendrag

Context Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential measurements onto a chart. Reference curve modeling is applicable to endocrine variables and represents a standardized method to account for variation with gender and age. Objective We aimed to establish gender-specific biomarker reference curves for clinical use and benchmark associations between hormones, pubertal phenotype, and body mass index (BMI). Methods Using cross-sectional population sample data from 2139 healthy Norwegian children and adolescents, we analyzed the pubertal status, ultrasound measures of glandular breast tissue (girls) and testicular volume (boys), BMI, and laboratory measurements of 17 clinical biomarkers modeled using the established “LMS” growth chart algorithm in R. Results Reference curves for puberty hormones and pertinent biomarkers were modeled to adjust for age and gender. Z-score equivalents of biomarker levels and anthropometric measurements were compiled in a comprehensive beta coefficient matrix for each gender. Excerpted from this analysis and independently of age, BMI was positively associated with female glandular breast volume (β = 0.5, P 

Bidragsytere

Andre Madsen

  • Tilknyttet:
    Forfatter
    ved Hormonlaboratoriet ved Helse Bergen HF - Haukeland universitetssykehus

Bjørg Almås

  • Tilknyttet:
    Forfatter
    ved Hormonlaboratoriet ved Helse Bergen HF - Haukeland universitetssykehus

Ingvild Særvold Bruserud

  • Tilknyttet:
    Forfatter
    ved Fakultet for helsefag ved VID vitenskapelige høgskole
  • Tilknyttet:
    Forfatter
    ved Barneklinikken ved Helse Bergen HF - Haukeland universitetssykehus

Ninnie Helen Bakken Oehme

  • Tilknyttet:
    Forfatter
    ved Barneklinikken ved Helse Bergen HF - Haukeland universitetssykehus

Christopher Sivert Nielsen

  • Tilknyttet:
    Forfatter
    ved Avdeling for fysisk helse og aldring ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF
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