Cristin-resultat-ID: 2035310
Sist endret: 31. januar 2023, 09:19
NVI-rapporteringsår: 2022
Resultat
Vitenskapelig artikkel
2022

A Cease in Shift Work Reverses Arterial Stiffness but Increases Weight and Glycosylated Hemoglobin A 5-Month Follow-Up in Industry

Bidragsytere:
  • Marit Skogstad
  • Hans Christian Dalsbotten Aass
  • Lars-Kristian Lunde
  • Øivind Skare
  • Per Anton Sirnes og
  • Dagfinn Matre

Tidsskrift

Journal of Cardiovascular Development and Disease (JCDD)
ISSN 2308-3425
e-ISSN 2308-3425
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2022
Volum: 9
Hefte: 6
Artikkelnummer: 190
Open Access

Importkilder

Scopus-ID: 2-s2.0-85132311753

Klassifisering

Emneord

Skiftarbeid • Arteriell stivhet • Kardiovaskulær • Yrkessundhet

Beskrivelse Beskrivelse

Tittel

A Cease in Shift Work Reverses Arterial Stiffness but Increases Weight and Glycosylated Hemoglobin A 5-Month Follow-Up in Industry

Sammendrag

Background: Literature suggests an association between shift work and cardiovascular disease (CVD). Limited evidence is available on how a cessation of shift work affects CVD risk factors. Aim: We investigated whether a five-month plant shutdown affected CVD risk factors in 30 industrial shift workers. Methods: We collected demographic data, self-reported data on physical activity (PA) and medical history by questionnaire. Pre- and post-plant shutdown, we measured blood pressure (BP), heart rate, lipids, glycosylated hemoglobin (HbA1c) and C-reactive protein (CRP). Additionally, we collected markers of inflammation, Matrix metalloproteinase-9 (MMP-9), Interleukin-6 (IL-6), Monocyte chemoattractant protein-1 (MCP-1), Tumor necrosis factor-alpha (TNF-α), P-selectin, Interleukin-1 beta (IL-1β), and Interleukin-23 (IL-23). We also examined arterial stiffness (central blood pressure, augmentation pressure, and pulse wave velocity) by means of SphygmoCor® (AtCor Medical Pty Ltd., Sydney, Australia). We monitored sleep by actigraphy prior to and after plant shutdown, with additional registration of sleep quality and assessment of insomnia symptoms. Results: After five months of plant shutdown, we found that HbA1c increased by 1.9 mmol/mol, weight by 1 kg and MCP-1 by 27.3 pg/mL, all unexpectedly. The other markers of inflammation did not change during shutdown, but CRP decreased close to significant levels. There were no changes in lipids during follow-up. Pulse-wave velocity (PWV) was reduced from 8.1 m/s (SD = 1.5) to 7.6 m/s (SD = 1.5), p = 0.03. The workers reported fewer signs of insomnia after shutdown. Conclusions: Our findings suggest that a five-month cessation in shift work increases weight and HbA1c, but also improves insomnia symptoms and reverses arterial stiffening.

Bidragsytere

Marit Skogstad

  • Tilknyttet:
    Forfatter
    ved Statens arbeidsmiljøinstitutt

Hans Christian Aass

Bidragsyterens navn vises på dette resultatet som Hans Christian Dalsbotten Aass
  • Tilknyttet:
    Forfatter
    ved Avdeling for medisinsk biokjemi ved Oslo universitetssykehus HF

Lars-Kristian Lunde

  • Tilknyttet:
    Forfatter
    ved Statens arbeidsmiljøinstitutt

Øivind Skare

  • Tilknyttet:
    Forfatter
    ved Statens arbeidsmiljøinstitutt

Per Anton Sirnes

  • Tilknyttet:
    Forfatter
    ved Østlandske Hjertesenter
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