Cristin-resultat-ID: 2062063
Sist endret: 19. februar 2023, 20:25
NVI-rapporteringsår: 2022
Resultat
Vitenskapelig artikkel
2022

Clinical Outcome of Viral Respiratory Tract Infections in Hospitalized Adults in Norway: High Degree of Inflammation and Need of Emergency Care for Cases With Respiratory Syncytial Virus

Bidragsytere:
  • Sara Molvig Debes
  • Jon Birger Haug
  • Birgitte Freiesleben De Blasio
  • Jonas Christoffer Lindstrøm
  • Christine M Jonassen og
  • Susanne Gjeruldsen Dudman

Tidsskrift

Frontiers in medicine
ISSN 2296-858X
e-ISSN 2296-858X
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2022
Publisert online: 2022
Volum: 9
Artikkelnummer: 866494
Open Access

Importkilder

Scopus-ID: 2-s2.0-85130219735

Beskrivelse Beskrivelse

Tittel

Clinical Outcome of Viral Respiratory Tract Infections in Hospitalized Adults in Norway: High Degree of Inflammation and Need of Emergency Care for Cases With Respiratory Syncytial Virus

Sammendrag

Background: The clinical features and outcomes of viral respiratory tract infections (RTIs) in adults have not been thoroughly studied, especially the respiratory syncytial virus (RSV) disease burden. It has become apparent that outbreaks of RSV in the elderly are associated with increased hospitalization rates. However, little data exists on the severity of such viral RTIs in adults, particularly the need for hospitalization, respiratory support and intensive care. Methods: We conducted a retrospective observational single-center study at Østfold Hospital Trust, Norway, during three winter seasons 2015–2018. Patients ≥18 years with either influenza A, influenza B, RSV A/B, human metapneumovirus, parainfluenza virus 1–4 or adenovirus detected in respiratory specimens were included, if they were hospitalized 14 days prior or following the detection date, with signs of RTI. Hospital records on treatment and outcome were investigated, as well as mortality of all causes up to 30 days from discharge. Results: Of the 1222 infection events that were included, influenza A was the most frequent virus detected (39%), while 179 infection events (14.6%) were due to RSV. Influenza B counted for 24% of the infection events, human metapneumovirus 13%, parainfluenza virus 9% and adenovirus 1%. Patients admitted with RSV more often suffered from COPD and congestive heart failure than patients with influenza A. In addition, RSV patients were overrepresented in the urgent response NEWS score (National Early Warning Score) category ≥5. RSV patients also showed signs of more severe inflammation, with WBC ≥11.1 × 109/L and CRP >100 mg/L, and they were more often treated with antibiotic agents during their hospital stay. However, we found no differences in the need for ICU admission or mortality. Conclusion: Patients with RSV had more often high values for markers of inflammation and elevated NEWS score when compared to patients hospitalized with other common respiratory viruses. Taken into account that they suffered more frequently from comorbidities like COPD, these patients needed hospitalization more urgently. These findings highlight the need for further investigations on RSV disease in adults and the elderly.

Bidragsytere

Sara Molvig Debes

  • Tilknyttet:
    Forfatter
    ved Senter for laboratoriemedisin ved Sykehuset Østfold HF
  • Tilknyttet:
    Forfatter
    ved Avdeling for mikrobiologi ved Universitetet i Oslo

Jon Birger Haug

  • Tilknyttet:
    Forfatter
    ved Fag og utvikling ved Sykehuset Østfold HF

Birgitte Freiesleben de Blasio

Bidragsyterens navn vises på dette resultatet som Birgitte Freiesleben De Blasio
  • Tilknyttet:
    Forfatter
    ved Stokastiske modeller og inferens ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Avdeling for metodeutvikling og analyse ved Folkehelseinstituttet

Jonas Christoffer Lindstrøm

  • Tilknyttet:
    Forfatter
    ved Avdeling for metodeutvikling og analyse ved Folkehelseinstituttet

Christine Genevieve Monceyron Jonassen

Bidragsyterens navn vises på dette resultatet som Christine M Jonassen
  • Tilknyttet:
    Forfatter
    ved Senter for laboratoriemedisin ved Sykehuset Østfold HF
  • Tilknyttet:
    Forfatter
    ved Avdeling for virologi ved Folkehelseinstituttet
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