Cristin-resultat-ID: 344479
Sist endret: 25. oktober 2016 14:35
Resultat
Vitenskapelig artikkel
1997

Outer membrane vesicle vaccines made from short- chain lipopolysaccharide mutants of serogroup B Neisseria meningitidis: effect of carbohydrate chain length on the immune response

Bidragsytere:
  • SR Andersen
  • Gunnar Bjune
  • Ernst Arne Høiby
  • Terje Einar Michaelsen
  • Audun Aase
  • Unni Kristine Rye
  • mfl.

Tidsskrift

Vaccine
ISSN 0264-410X
e-ISSN 1873-2518
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 1997
Volum: 15
Sider: 1225 - 1234

Beskrivelse Beskrivelse

Tittel

Outer membrane vesicle vaccines made from short- chain lipopolysaccharide mutants of serogroup B Neisseria meningitidis: effect of carbohydrate chain length on the immune response

Sammendrag

Outer membrane vesicle (OMV) vaccines were made from Neisseria meningitidis strain 44/76 and its two short-chain lipopolysaccharide (LPS) mutants, Mu-1 and Mu-4. Only the 44/76 vaccine contained LPS with the host antigen lacto-N-neotetraose. The protein composition of the vaccines was similar. The LPS carbohydrate chain length proved to influence drastic changes in the LPS immunogenicity as well as the outer membrane proteins (OMPs) ability to elicit functional antibodies in mice. Only LPS in the Mu-1 and Mu-4 vaccines were immunogenic, and the 44/76 vaccine differed also by not inducing antibodies to the class 4 OMP. The Mu-1 vaccine, with a LPS carbohydrate chain comprising only two residues of 2-keto-3-deoxy-octonic acid, induced lower bactericidal activity and less antibodies to the class 1 OMP, compared to the two other vaccines. This indicates that LPS of a certain carbohydrate chain length is required for adequate exposure of the class 1 OMP epitopes essential for inducing bactericidal antibodies

Bidragsytere

SR Andersen

  • Tilknyttet:
    Forfatter
Aktiv cristin-person

Gunnar Aksel Bjune

Bidragsyterens navn vises på dette resultatet som Gunnar Bjune
  • Tilknyttet:
    Forfatter

Ernst Arne Høiby

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Terje Einar Michaelsen

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Audun Aase

  • Tilknyttet:
    Forfatter
    ved Avdeling for infeksjonsimmunologi ved Folkehelseinstituttet
1 - 5 av 7 | Neste | Siste »