Cristin-resultat-ID: 344628
Sist endret: 25. oktober 2016 14:35
Resultat
Vitenskapelig artikkel
1998

Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine

Bidragsytere:
  • Lisbeth Meyer Næss
  • Fredrik Oftung
  • Audun Aase
  • L Wetzler
  • Randi Helene Sandin og
  • Terje Einar Michaelsen

Tidsskrift

Infection and Immunity
ISSN 0019-9567
e-ISSN 1098-5522
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 1998
Volum: 66
Sider: 595 - 600

Beskrivelse Beskrivelse

Tittel

Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine

Sammendrag

We have analyzed human T-cell responses in parallel with serum immunoglobulin G (IgG) antibody levels after systemic vaccination with the Norwegian group B Neisseria meningitidis outer membrane vesicle (OMV) vaccine. Ten adult volunteers, with no or very low levels of serum IgG antibodies against meningococci, received three doses intramuscularly of the OMV vaccine (at weeks 0, 6, and 46). T-cell proliferation against the OMV vaccine, purified outer membrane proteins (PorA and PorB), and control antigens (Mycobacterium bovis BCG vaccine and tetanus toxoid) was measured by thymidine incorporation of peripheral blood mononuclear cells before and after vaccination. The results showed that vaccination with OMV elicits strong primary and booster T-cell responses specific to OMV as well as the PorA (class 1) protein and significant, but markedly lower, responses against the PorB (class 3) protein. The median responses to OMV and PorA were 26 and 16 times the prevaccination levels, respectively. Most of the vaccinees showed low T-cell responses against OMV and PorA before vaccination, and the maximum T-cell responses to all vaccine antigens were usually obtained after the second vaccine dose. We found a positive correlation between T-cell responses and anti-OMV IgG antibody levels (r = 0.50, P

Bidragsytere

Lisbeth Meyer Næss

  • Tilknyttet:
    Forfatter
    ved Avdeling for vaksineforebyggbare sykdommer ved Folkehelseinstituttet

Fredrik Oftung

  • Tilknyttet:
    Forfatter
    ved Avdeling for infeksjonsimmunologi ved Folkehelseinstituttet

Audun Aase

  • Tilknyttet:
    Forfatter
    ved Avdeling for infeksjonsimmunologi ved Folkehelseinstituttet

L Wetzler

  • Tilknyttet:
    Forfatter

Randi Helene Sandin

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet
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