Cristin-resultat-ID: 345976
Sist endret: 25. oktober 2016 14:35
Resultat
Vitenskapelig artikkel
1998

Effect of aluminium hydroxide and meningococcal serogroup C capsular polysaccharide on the immynogenisity og a group B Neisseria meningitidis outer mebrane vesicle vaccine

Bidragsytere:
  • Einar Rosenqvist
  • Ernst Arne Høiby
  • Gunnar Bjune
  • Audun Aase
  • A Halstensen
  • AK Lehman
  • mfl.

Tidsskrift

Developments in Biological Standardization
ISSN 1424-6074

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 1998
Volum: 92
Sider: 323 - 333

Beskrivelse Beskrivelse

Tittel

Effect of aluminium hydroxide and meningococcal serogroup C capsular polysaccharide on the immynogenisity og a group B Neisseria meningitidis outer mebrane vesicle vaccine

Sammendrag

Three different formulations of an outer membrane vesicle (OMV) vaccine against group B meningococcal disease have been prepared and tested for immunogenicity and reactogenicity in adult volunteers. The vaccines were prepared with or without aluminium hydroxide and serogroup C-polysaccharide (C-ps). Doses from 12.5 to 100 micrograms protein were given twice at a six weeks' interval. All three formulations were well tolerated and highly immunogenic, inducing bactericidal and opsonizing antibodies in humans. Adsorption of OMVs to aluminium hydroxide reduced the pyrogenicity in rabbits. The differences in immunogenicity between the formulations were relatively small, but after the second dose a stronger booster response was observed when the vaccines were adsorbed. Thus, a formulation with OMVs and C-ps represents a safe and highly immunogenic vaccine, even without aluminium hydroxide

Bidragsytere

Einar Ivanovitsj Rosenqvist

Bidragsyterens navn vises på dette resultatet som Einar Rosenqvist
  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Ernst Arne Høiby

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet
Aktiv cristin-person

Gunnar Aksel Bjune

Bidragsyterens navn vises på dette resultatet som Gunnar Bjune
  • Tilknyttet:
    Forfatter

Audun Aase

  • Tilknyttet:
    Forfatter
    ved Avdeling for infeksjonsimmunologi ved Folkehelseinstituttet

Alfred Halstensen

Bidragsyterens navn vises på dette resultatet som A Halstensen
  • Tilknyttet:
    Forfatter
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