Cristin-resultat-ID: 350685
Sist endret: 25. oktober 2016 14:35
Resultat
Vitenskapelig artikkel
1995

Comparison among opsonic activity, antimeningococcal immunoglobulin G response, and serum bactericidal activity against meningococci in sera from vaccinees after immunization with a serogroup B outer membrane vesicle vaccine

Bidragsytere:
  • Audun Aase
  • GA Bjune
  • Ernst Arne Høiby
  • Einar Rosenqvist
  • AK Pedersen og
  • Terje Einar Michaelsen

Tidsskrift

Infection and Immunity
ISSN 0019-9567
e-ISSN 1098-5522
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 1995
Volum: 63
Sider: 3531 - 3536

Beskrivelse Beskrivelse

Tittel

Comparison among opsonic activity, antimeningococcal immunoglobulin G response, and serum bactericidal activity against meningococci in sera from vaccinees after immunization with a serogroup B outer membrane vesicle vaccine

Sammendrag

Opsonic activity in sera from 27 military recruits vaccinated with the Norwegian meningococcal serogroup B outer membrane vesicle vaccine was measured as respiratory burst with polymorphonuclear leukocytes as the effector cells and meningococci of the epidemic strain as the target. The results were compared with antimeningococcal IgG antibodies against an outer membrane vesicle coat in an enzyme-linked immunosorbent assay and with serum bactericidal activity. The vaccinees were immunized twice, with a 6-week interval between the two. The serum samples studied were collected at day zero, after 6 weeks, and after 12 weeks. Both serum bactericidal activity and respiratory burst were measured by adding external serum as the complement source. The results revealed a significant increase in specific IgG response, serum bactericidal activity, and respiratory burst after vaccination. We found a highly significant correlation between the responses in all three assays (P

Bidragsytere

Audun Aase

  • Tilknyttet:
    Forfatter
    ved Avdeling for infeksjonsimmunologi ved Folkehelseinstituttet
Aktiv cristin-person

Gunnar Aksel Bjune

Bidragsyterens navn vises på dette resultatet som GA Bjune
  • Tilknyttet:
    Forfatter

Ernst Arne Høiby

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Einar Ivanovitsj Rosenqvist

Bidragsyterens navn vises på dette resultatet som Einar Rosenqvist
  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

AK Pedersen

  • Tilknyttet:
    Forfatter
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