Cristin-resultat-ID: 364446
Sist endret: 2. juni 2017 12:07
Resultat
Vitenskapelig artikkel
2006

A first insight into the genetic diversity of Mycobacterium tuberculosis in Dar es Salaam, Tanzania, assessed by spoligotyping

Bidragsytere:
  • Vegard Eldholm
  • Mecky Matee
  • Sayoki Godfrey M. Mfinanga
  • Manfred Heun og
  • Ulf Reidar Dahle

Tidsskrift

BMC Microbiology
ISSN 1471-2180
e-ISSN 1471-2180
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2006
Volum: 6
Artikkelnummer: 76
Open Access

Importkilder

Isi-ID: 000240992300001

Beskrivelse Beskrivelse

Tittel

A first insight into the genetic diversity of Mycobacterium tuberculosis in Dar es Salaam, Tanzania, assessed by spoligotyping

Sammendrag

BACKGROUND: Tanzania has a high tuberculosis incidence, and genotyping studies of Mycobacterium tuberculosis in the country are necessary in order to improve our understanding of the epidemic. Spoligotyping is a potentially powerful genotyping method due to fast generation of genotyping results, high reproducibility and low operation costs. The recently constructed SpolDB4 database and the model-based program 'Spotclust' can be used to assign isolates to families, subfamilies and variants. The results of a study can thus be analyzed in a global context. RESULTS: One hundred forty-seven pulmonary isolates from consecutive tuberculosis patients in Dar es Salaam were spoligotyped. SpolDB4 and 'Spotclust' were used to assign isolates to families, subfamilies and variants. The CAS (37%), LAM (22%) and EAI (17%) families were the most abundant. Despite the dominance of these three families, diversity was high due to variation within M. tuberculosis families. Of the obtained spoligopatterns, 64% were previously unrecorded. CONCLUSION: Spoligotyping is useful to gain an overall understanding of the local TB epidemic. This study demonstrates that the extensive TB epidemic in Dar es Salaam, Tanzania is caused by a few successful M. tuberculosis families, dominated by the CAS family. Import of strains was a minor problem

Tittel

A first insight into the genetic diversity of Mycobacterium tuberculosis in Dar es Salaam, Tanzania, assessed by spoligotyping

Bidragsytere

Vegard Eldholm

  • Tilknyttet:
    Forfatter
    ved Handelshøgskolen ved Norges miljø- og biovitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Mecky I Matee

Bidragsyterens navn vises på dette resultatet som Mecky Matee
  • Tilknyttet:
    Forfatter
    ved University of Dar es Salaam - Branch: Muhimbili University College of Health Sciences

Sayoki Godfrey M. Mfinanga

  • Tilknyttet:
    Forfatter
    ved University of Dar es Salaam - Branch: Muhimbili University College of Health Sciences

Manfred Heun

  • Tilknyttet:
    Forfatter
    ved Miljøvitenskap og naturforvaltning ved Norges miljø- og biovitenskapelige universitet

Ulf Reidar Dahle

  • Tilknyttet:
    Forfatter
    ved Smittevern, miljø og helse ved Folkehelseinstituttet
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